NINDS ADMINISTRATIVE SUPPLEMENTS FOR DNA MICROARRAY ANALYSIS

RELEASE DATE:  October 30, 2003
 
NOTICE:  NOT-NS-04-002

National Institute of Neurological Disorders and Stroke (NINDS)
 (http://www.ninds.nih.gov)

The National Institute of Neurological Disorders and Stroke (NINDS) announces 
an administrative supplement program of up to $1.0 million in Fiscal Year 
2004 to provide funds to NINDS-funded research projects to conduct gene 
expression profiling experiments on the nervous system.  This program is 
intended to facilitate access to DNA microarray analysis for peer-reviewed 
projects that have Specific Aims for which microarray analysis will provide 
clearly relevant data.  The supplemental funds may be used to execute primary 
experiments and isolate RNA in the grantee labs, and to purchase products and 
services from the NINDS/NIMH Microarray Consortium.  Animals and supplies may 
be requested for the home lab, with the remainder of the funds reserved for 
use of the microarray consortium.  No requests for salary or equipment will 
be considered.  Opportunities are available for investigators to visit the 
microarray centers to use the facilities for sample processing, including RNA 
extraction, amplification of small amounts of RNA, and laser-capture 
microdissection.  In cases where the research plan involves one or more 
visits to a consortium microarray center, travel funds for the visits may be 
requested.  Principal Investigators (PIs) with Research Project (R01 or U01), 
Exploratory/Developmental (R21), Phase II SBIR (R44), Program Project (P01), 
and Specialized Center (P50 or U54) grants are eligible to apply.  To be 
eligible, projects must be actively funded in fiscal year 2004.

Evidence should be presented that the results of the supplemental assistance 
will significantly enhance the pursuit of the Specific Aims of the research 
project, without constituting an expansion of scope.

The NINDS/NIMH Microarray Consortium was established to serve as a national 
resource to provide DNA microarray products and services to NINDS and NIMH 
grantees, on a fee-for-service basis.  The consortium is composed of three 
microarray centers, located at Duke University in Durham, NC, the 
Translational Genomics Research Institute in Phoenix, AZ, and the University 
of California in Los Angeles, CA.  The full spectrum of support for 
microarray studies is available through the consortium, including advice on 
experimental design, education and training of investigators, hybridization 
and scanning of arrays, bioinformatics support, and manuscript preparation 
assistance.  The consortium makes and provides spotted oligonucleotide and 
cDNA arrays, and supports the Agilent and Affymetrix platforms.

Further information on the microarray consortium is available on the 
consortium website (http://arrayconsortium.tgen.org), or by contacting the 
Consortium Coordinator, Sarah Brautigam, at 602-343-8732 or 
SBrautigam@tgen.org.  It is recommended that investigators contact the 
consortium in advance of preparing research plans or formulating budget 
requests to get preliminary advice on experimental design and to determine 
the approximate cost of using the consortium for the supplemental study.

How to Make a Request:  Applicants should submit an original and three 
complete copies to the NINDS program contact listed at the end of this 
Notice.  The following sections should be included:

1) A cover page citing this Notice and including the PI name, grant number 
and title, amount of the requested supplement, the name and title of the 
institutional official, and the phone, email, and address information for 
both the PI and institutional official.  Document the approval from the 
Institutional Animal Care and Use Committee (IACUC) for any use of vertebrate 
animals in the supplemental experiments.  For P01s, P50s, and U54s, the PI 
must submit a request for a supplement to a subproject.  The cover page must 
be signed by the PI and the institutional official.

2) A letter (5-page limit) describing the project, including an abstract, a 
description of the proposed experiments and their relationship to the 
original project Specific Aims, a discussion of the significance of the 
results, and a budget.

3) A Biographical Sketch of the PI.

4) The Specific Aims from the grant.

5) Documentation of institutional or other co-funding.

Budget Information:  Supplements will be made in modular amounts of $25,000.  
All awards are TOTAL COSTS.  Any Facilities & Administrative Costs (indirect 
costs) should be included in the modular request, and cannot be requested in 
addition to the modular amounts.  For all grant mechanisms the maximum 
supplement is $50,000.  Although the awarded budgets will be modular, 
applicants should provide a categorized budget justification.  Contributions 
from institutional and other sources may be combined with the requested 
award; such contributions should be documented.

Review Procedure:  Applications will be reviewed administratively.  Review 
criteria will be considered in the context of the Specific Aims of the parent 
grant and will include the scientific merit of the proposed study, the 
relevance to program priorities of NINDS, and the impact of the results for 
other areas in neuroscience.  It is anticipated that supplements will be 
awarded within four months of the receipt date.

RECEIPT DATE:  February 17, 2004

Inquiries should be directed to:

Thomas Miller, Ph.D.
Technology Development
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard, Room 2139
Bethesda MD 20892
Tel:  301-496-1779
Fax:  301-402-1501
Email:  tm208y@nih.gov

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