Release Date:  December 18, 2001

NOTICE:  NOT-NS-02-007

Update: July 7, 2009 – This Notice is superseded by NIH-OD-09-116 NIH Guidelines
for Human Stem Cell Research

National Institute of Neurological Disorders and Stroke ( The National Institute of Neurological Disorders and Stroke (NINDS) announces a program for administrative supplements to foster basic and applied research on human embryonic stem cells (hESCs), and to allow investigators not currently working on hESCs to join the field. This supplemental funding initiative is issued in response to recommendations from DHHS Secretary Thompson calling for funding studies to compare the behavior of hESCs with that of other human stem cells, and stem cells from non-human species. This program is intended to facilitate research within ongoing, peer-reviewed projects that have Specific Aims on stem cell biology, or Specific Aims that may translate to the use of stem cells in pre-clinical studies of neurological dysfunction. These one-time supplements are intended to help NINDS grantees develop preliminary data for new applications to NINDS. Principal Investigators (PIs) funded by NINDS with Research Project (R01), Exploratory/Developmental (R21), Phase II SBIR (R44), Program Project (P01), and Specialized Center (P50 or U54) grants are eligible to apply. To be eligible, projects must have a Project Period End Date of April 30, 2003, or later (a no-cost extension beyond that date does not confer eligibility). Only research using hES cell lines registered in the NIH Registry will be eligible for funding. Each approved cell line is specifically identified in the Registry, and it is the responsibility of the applicant to provide the official identifier(s) for their hESC lines as found in the NIH Registry ( Applications that do not provide this information will be returned without review. Evidence should be presented that the results of the supplemental assistance will enhance the pursuit of the Specific Aims of the research project, without constituting an expansion of scope. Supplements are one-time awards and will not extend to subsequent budget periods. Specific examples of supplemental requests that may be considered include, but are not limited to: o Studies on the basic cellular and molecular biology of hESCs within the framework of the existing project. o Analysis of hESCs behavior in animal models of injury or disease in the nervous system. Examples of these conditions include stroke, spinal cord and traumatic brain injury, Amyotrophic Lateral Sclerosis, Parkinson"s Disease, Ataxia Telangiectasia, and Multiple Sclerosis. o Requests within existing grants on the development of biomarkers or genetic tools for identifying, harvesting, purifying, and expanding hESCs and/or their differentiating progeny. How to Apply: Submission of requests should be made electronically. Send an email message to: with the PI"s name (last, first) and grant number on the subject line. Include the following items in an attached file in MSWord, WordPerfect, or PDF format. Please note: the e-mail address is case sensitive, use lower case only. 1) A cover page citing this NOTICE and requesting an administrative supplement. Include the PI name, grant number and title, amount requested, name and title of the institutional official, and phone, email, and address information for the PI and institutional official. For P01s, P50s, and U54s the overall project PI must submit the request for a supplement. 2) A letter (5-page limit) describing the proposed experiments and their relationship to the original project Specific Aims, a brief discussion of the significance of the proposed research, and a budget with justifications. In addition, an original cover letter signed by the PI and countersigned by the institutional official should be submitted by mail. The requested letter is not the cover page of the original grant, but is specific for this supplemental application. This documentation is required for the issuance of an award, and should be sent to Dr. Arlene Chiu, listed at the end of this notice. The application should be formatted as a memo or letter and provide the information listed above. PIs should not submit a request electronically until the institutional business office has reviewed and approved the request. Applicants unable to submit electronic applications should submit a complete written application addressed to the same NINDS contact. Budget Information: For FY 2002, the NINDS will commit $1 million (total costs) to fund applications for supplements submitted in response to this Notice. The Christopher Reeve Paralysis Foundation will commit $250,000, and the ALS Association and the A-T Children’s Project each will commit $50,000. Although the financial plans of the NINDS and the Foundations provide support for this program, awards pursuant to this Notice are contingent upon the availability of funds and the receipt of a sufficient number of applications high scientific merit. Supplements will be awarded as TOTAL COSTS, and are one-time awards. Any Facilities and Administrative (F&A) costs should be included in the modular request, and may not be added to it. For R01s, R21s, and R44s the maximum request is $50,000. For P01s, P50s, and U54s the maximum is $100,000. Although the awarded budgets will be modular, applicants should provide budget justification that details the budget items requested, including F&A costs. Review Procedures: Requests will be reviewed administratively. Review criteria will include the scientific significance and relevance to program priorities of the institute. Post-Award Requirements: A short, 1-page progress report addressing the results of the supplement will be required. It should be included as an addition to the next progress report of the parent grant, submitted after the one year supplement. Receipt Date: February 15, 2002 Earliest Award Date: May 15, 2002 Inquiries: A website with Frequently Asked Question"s about the program has been provided at: Direct inquiries regarding scientific issues to: Dr. Arlene Y. Chiu Program Director, Repair and Plasticity Program National Institute of Neurological Disorders and Stroke 6001 Executive Blvd. NSC Rm. 2205 Bethesda, MD 20892 Tel: (301) 496-1447 Fax: (301) 480-1080 Email: Direct inquiries regarding application issues to: Dr. Meredith Temple Program Analyst, Repair and Plasticity Program National Institute of Neurological Disorders and Stroke 6001 Executive Blvd. NSC Rm. 2227 Bethesda, MD 20892 Tel: (301) 496-1447 Fax: (301) 480-1080 Email: Direct inquiries regarding fiscal matters to: Rita Sisco Grants Management Branch National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., NSC 3290 Bethesda, Maryland 20892 Tel: 301-496-9231 Fax: 301-402-0219 Email:

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H H S Department of Health
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  N I H National Institutes of Health (NIH)
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