Notice of Availability of One-Year Administrative Supplements to NIMH-supported Research for FY 2012

Notice Number: NOT-MH-12-014

Key Dates
Release Date: January 23, 2012
Receipt Date:  March 22, 2012
Earliest Anticipated Start Date:  June 1, 2012

Issued by
National Institute of Mental Health (NIMH)


The National Institute of Mental Health (NIMH) announces opportunities for investigators with active NIMH-supported research grants to request 1 year of supplemental funding in FY2012.  NIMH has identified specific areas of interest in accordance with its goal of accelerating mental health research as described in the Institute’s Strategic Plan.

All supplement requests must be received by March 22, 2012, 5 pm local time of applicant organization.  All applications should be preceded by consultation with the NIMH Program Staff associated with the parent grant to discuss the potential supplement request. 

NIMH priority research areas to be considered for 1-year of supplemental funding in FY2012:

  1. Administrative Supplements to Obtain Data on Neural Connectivity in Ongoing Neuroimaging Studies of Early Development and Aging.  The intent of this one-year supplemental topic is to capitalize on NIMH’s current neuroimaging investments in young and aging populations to obtain additional data focused specifically on connectivity, e.g., resting state fMRI, diffusion imaging, and/or application of other techniques to address connectivity across brain regions (e.g., task-based fMRI, magnetoencephalography, and electroencephalography).  Eligible ongoing grants should have subject populations in infancy, childhood, adolescence, or adulthood beyond age 35.  Supplements will facilitate comparisons among connectivity and other imaging assessments within and across studies and provide pilot data for future studies on normative development, aging and/or risk.

  2. Administrative Supplements to Encourage Integration, Data Sharing, and Standardization.  The intent of this one-year administrative supplement topic is to develop and implement data sharing plans among funded NIMH investigators.  The NIH requires that all investigator-initiated applications with direct costs greater than $500,000 in any single year develop a data sharing plan (see NIH Data Sharing Policy and NOT-OD-03-032). Consistent with NIMH’s efforts to facilitate standardization, integration, and data sharing across projects, this supplement opportunity is directed to those NIMH-supported grants with a direct cost at or less than $500,000 that are not currently mandated to develop data sharing plans, and for which data sharing could afford important scientific advantages.  A goal is to promote collaboration among scientists and institutions for new discoveries through enhanced statistical power, innovative and multi-level analyses, and data modeling.  Priority will be given to requests that will significantly accelerate scientific discovery through the harmonization of efforts or sharing of data.

Although applications for supplements may be submitted by a single Program Director/Principal Investigator (PD/PI) to develop and implement a data sharing plan, NIMH will give special consideration to ‘linked’ supplement applications from multiple basic and/or clinical investigators who are studying a related topic (e.g., disorder, dimension, mechanism) and propose to share data across studies and engage with a common storage/use platform.

Activities supported under this topic area may include, but are not necessarily limited to:

  1. Standardizing and Integrating Data from Conceptually Related Clinical Research Studies.  The intent of this one-year administrative supplement topic to current NIMH-supported clinical research studies is to foster standardization of measures, data aggregation, and sharing of pooled data among projects that are similar in terms of target samples, research aims, variables, methods, and/or conceptual framework.  The aim is to create scientifically integrated, federated databases that will support analysis of pooled data from multiple independent projects.  
  1. Advancing the Development of one or more Biomarkers for Use in Clinical Research.  The intent of this one-year administrative supplement topic is to leverage current NIMH investments to facilitate the initial testing of potential biomarkers that may have predictive value for disease onset, progression, remission, or treatment response.  The supplement request must provide a strong rationale for the proposed research effort, clarifying the potential utility of the targeted biomarker(s), specific analyses needed to ready them for use in future research or the other scientific opportunity to be served by the additional data collection, and the feasibility of completing the required work within the scope and remaining funding period of the current project.  The investigator must clearly describe how the additional data to be obtained will be combined with other information available within the project or from other sources so as to enable analyses that will contribute substantially to advancing the targeted biomarker development.  As appropriate to the design and aims of the existing study, the supplemental request may focus on development of any of a variety of biomarker types (e.g., markers of disease risk, pathophysiological process, disease severity or progression, response to treatment).
  1. Documenting the Potential Public Health Impact of Intervention Research by Adding/Broadening Cost Analyses to Existing Studies.The intent of this one-year administrative supplement topic focuses on estimating the potential net cost savings of promising preventive/treatment/health services interventions from the payer’(s) (Medicaid, Medicare, private insurance, patient) perspective. Supplement requests should propose economic modeling that account both for changes in expenditures resulting from the intervention and the cost of implementing and operating the program. For consistency in reporting, it is expected that investigators will calculate the cost savings per capita, the total cost savings for the payer(s) and the return on investment (ROI) ratio in 2010 Dollars.

Budget and Funding Information

To be considered for FY2012 funds, Administrative Supplement requests must be received by March 22, 2012, 5 pm local time of applicant organization.  All applications should be preceded by consultation with the NIMH Program Staff associated with the parent grant to discuss the potential supplement request. 

All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

An award issued under this Notice is contingent upon adequate progress on the parent grant during the current project period, an evaluation of the unoblicated balance for the budget period, the availability of funds, and the receipt of a sufficient number of meritorious applications.


Applications for these FY 2012 Administrative Supplements must meet the following criteria:

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, the request must be signed by the Authorized Organizational Representative/Signing Official (AOR/SO), and must describe the need for additional funding and the categorical costs.

All requests for Administrative Supplements must be submitted electronically via the following link:

The Administrative Supplement request packet must include:

  1. Cover Letter – The cover letter must be signed by the authorized organizational representative and should indicate that you are requesting an Administrative Supplement in response to NOT-MH-12-014.  The content of the letter should include the following information:
  1. PHS 398 Form Page 1 (Face page) MS Word PDF
  1. PHS 398 Form page 2 MS Word PDF  Note: The project “summary” is that of the administrative supplement, not the parent grant. All other information requested on Form Page 2 should be provided.
  1. A brief application describing the project, including:
  1. PHS 398 Checklist Form MS Word PDF

Selection Factors

Administrative supplement requests will be reviewed administratively by NIMH Program and Grants Management Staff.  Selection factors will include the following:


Specific questions regarding eligibility or questions about the science to be proposed, should be directed to the NIMH Program Official for the parent grant.

For general information on Administrative Supplements or questions on how to submit contact:
Tracy Waldeck, Ph.D.
Branch Chief, Extramural Policy Branch
National Institute of Mental Health
Telephone: (301) 435-0322

For financial or grants management questions contact:
Rebecca Claycamp, M.S., CRA
Chief Grants Management Officer
National Institute of Mental Health
6001 Executive Boulevard, Room 6115, MSC 9605
Bethesda, MD 20892-9605
Telephone: 301-402-7111

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