Notice Number: NOT-MH-10-031

Key Dates
Release Date: August 16, 2010

Issued by
National Institute of Mental Health, (http://www.nimh.nih.gov)
National Institute of Neurological Disease and Stroke (NINDS), (http://www.ninds.nih.gov)

Purpose

The purpose of this notice is to correct a typographical error in the Research Objectives section of two Requests for Applications:  RFA-MH-11-020-(R01) and RFA-MH-11-021-(R21) - . Viral and Host Genetic Factors Regulating HIV-Associated CNS Disease.

The third paragraph of the Research Objectives section is corrected to read as follows: (the correction is identified in bold)

“Discordant compartmentalized viral evolution in the CNS has also received considerable attention and is a critical area since the majority of currently available anti-retrovirals poorly penetrate the brain. Viral evolution in the brain may also have an impact on disease course. For example, recent studies using sophisticated phylogenetic analysis of HIV-Nef, gp120 and gp41 sequences from demented and non-demented cases showed a relationship between HIV-1 evolutionary patterns in the brain and different neuropathologies. Viral evolution in the CNS may also have adaptive significance since recent studies also demonstrated divergence between lymphoid and brain derived HIV-1 Nef genes.”

All other aspects of these two funding opportunities remain unchanged.

Inquiries

Inquiries regarding this Notice may be directed to:

Jeymohan Joseph, Ph.D.
Division of AIDS Research
National Institute of Mental Health
6001 Executive Boulevard, Room 6219, MSC 9619
Rockville, MD  20892
Telephone: (301) 443-6100
Email: jjeymoha@mail.nih.gov

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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