Notice Number: NOT-MH-10-018

Key Dates
Release Date: May 21, 2010

Issued by
National Institute of Mental Health (http://www.nimh.nih.gov)

Purpose

The National Institute of Mental Health (NIMH) intends to issue a Request for Applications (RFA) for the following award: Viral and Host Genetic Factors Regulating HIV-Associated CNS Disease.  This award seeks to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART).  Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the host, the virus, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND.  The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, deep sequencing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors that influence the pathophysiology of HAND are encouraged. 
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This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The RFA is expected to be published in the summer of 2010.  This RFA will utilize the R01 award mechanism.

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Interested parties may contact:

Jeymohan Joseph, Ph.D.
Division of AIDS Research
National Institute of Mental Health
6001 Executive Boulevard, Room 6219, MSC 9619
Rockville, MD  20892-9619
Telephone: (301) 443-6100
Email: [email protected]