Clarification of Genotype Data Collection and Project Management for RFA MH-10-020 - The Human Connectome Project (U54)

Notice Number: NOT-MH-10-004

Key Dates
Release Date: October 28, 2009
Application Receipt Date:  November 24, 2009

Issued by
NIH Blueprint for Neuroscience Research (
National Center for Complementary and Alternative Medicine (NCCAM) (
National Center for Research Resources (NCRR) (
National Eye Institute (NEI) (
National Institute on Aging (NIA) (
National Institute on Alcohol Abuse and Alcoholism (NIAAA) (
National Institute of Biomedical Imaging and Bioengineering (NIBIB) (
National Institute of Child Health and Human Development (NICHD) (
National Institute on Deafness and Other Communication Disorders (NIDCD) (
National Institute of Dental and Craniofacial Research (NIDCR) (
National Institute on Drug Abuse (NIDA) (
National Institute of Environmental Health Sciences (NIEHS) (
National Institute of General Medical Sciences (NIGMS) (
National Institute of Mental Health (NIMH) (
National Institute of Neurological Disorders and Stroke (NINDS) (
National Institute of Nursing Research (NINR) (
Office of Behavioral and Social Sciences Research (OBSSR) (


The purpose of this Notice is to clarify issues regarding the collection of genotype data and the use of professional project management for RFA-MH-10-020 “The Human Connectome Project,” which was issued on July 15, 2009. 

Technological advances that have transpired since RFA-MH-10-020 was written have made it possible for larger numbers of subjects to be imaged than was envisioned in that FOA.  Images represent the principle data type to be collected for this project; ancillary data to be collected includes genotyping using chip technology.  Since the cost of chips for genotyping is not insignificant, the requirement to genotype each subject presents a budgetary trade-off which increases as more and more subjects are included in the project.  To mitigate the effect of this trade-off on the ability to image large numbers of subjects, rather than requiring that each subject be genotyped, only 500 subjects will be required to be genotyped.  If an applicant wishes to genotype all subjects, even beyond 500, that is also acceptable.  All other ancillary data collection (e.g., demographic, behavioral assessment) is expected from all subjects as described in RFA-MH-10-020.  And, blood samples are expected to be collected from all subjects as described in RFA-MH-10-020.

Professional project management is paramount to the performance of the Human Connectome Project.  Applicants who have questions about what constitutes professional project management, how roles of principal investigator and project manager compare to each other, and other issues related to this important aspect of the project are encouraged to contact the program officer listed below.


Specific questions about this Notice should be directed to:

Michael F. Huerta, Ph.D.
National Institute of Mental Health
6001 Executive Boulevard, Room 7202, MSC 9645
Bethesda, MD 20892-9645
Telephone: (301) 443-1815
FAX: (301) 443-1731

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