Request for Information (RFI): Procurement of Knockout Mice for Neuroscience Research

Notice Number: NOT-MH-05-016

Key Dates
Release Date: September 1, 2005

Issued by
National Institute of Mental Health (NIMH), (


This is a time-sensitive RFI directed toward neuroscience researchers. Participating Institutes/Centers from the NIH Blueprint for Neuroscience ( have been involved in extensive discussions to acquire hundreds of existing phenotyped knockout mice, which will be chosen from 1840 available strains from selected commercial suppliers under contract.  The selected strains will be available to the academic/non-profit research community through NIH-supported central repositories, and the phenotypic data will be available to all without restriction via public databases.  The NIH Institutes supporting neuroscience research request your assistance in nominating mouse lines that would be most valuable for neurobiological studies. There is a rapid turnaround from the time nominations are made, to the time the acquisition orders are placed, so a two-step process has been devised to receive your input as efficiently as possible.

Information Requested

Your first step is to request a listing of available knockout mice. To receive an email with the listings of available strains, please email with the heading “Requesting List” in the subject line.  In the second step, those who have requested the list will receive an email with an attached spreadsheet containing all available mouse lines. You will also receive further instructions on how to nominate strains of interest. Responses/rankings need to be returned as soon as possible, but no later than September 8. Nominations coming in after that date will not be considered for this initial acquisition.

The NIH appreciates your feedback; however, since only a subset of strains can be acquired, please note that not all nominations will be successful.


For questions and further information please contact:

Andrea C. Beckel-Mitchener Ph.D., Program Officer
John Grossi, Program Analyst
National Institute of Mental Health
Division of Neuroscience and Basic Behavioral Science
6001 Executive Boulevard, Room 7187, MSC 9641
Bethesda, MD 20892-9641
Telephone:  (301) 443-5288

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