Notice of Intent to Publish a Funding Opportunity Announcement for Pediatric Heart Network Clinical Research Centers (UM1)
Notice Number:

Key Dates

Release Date:
August 25, 2022
Estimated Publication Date of Funding Opportunity Announcement:
November 28, 2022
First Estimated Application Due Date:
February 23, 2023
Earliest Estimated Award Date:
October 24, 2023
Earliest Estimated Start Date:
November 24, 2023
Related Announcements


Issued by

National Heart, Lung, and Blood Institute (NHLBI)


The National Heart, Lung, and Blood Institute (NHLBI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications from qualified institutions willing to participate with NHLBI in the Pediatric Heart Network (PHN) as Clinical Research Centers (CRCs). These Clinical Research Centers will be expected to support and conduct research to improve the health and quality of life for children and adults with congenital heart disease through multi-center collaborative clinical research. Collaboration among the Clinical Research Centers, the Data Coordinating Center and other stakeholders is expected to facilitate multi-center evaluation of medical, interventional and surgical therapies; provide a training platform for fellows, junior faculty, and nurses; support development of novel treatment techniques and methodologies; and promote dissemination of study results to improve the scientific basis for the care of affected individuals. NHLBI plans to issue a companion FOA for the PHN Data Coordinating Center.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful cross-disciplinary collaborations and responsive projects.These may include but are not limited to investigators with experience in areas such as mechanistic and discovery science; genetics; neurodevelopment and mental health; diversity, equity, and inclusion; social determinants of health, and medical devices.

The intended FOA is expected to be published in the Fall of 2022, with an expected application due date in Spring 2023. The FOA will utilize the UM1 Research Project with Complex Structure Cooperative Agreement activity code.

Additional details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into clinical pediatric cardiovascular research and study conduct to begin to consider applying for the new planned FOA.

The objectives of the PHN are to provide an infrastructure for equitable multi-center collaborative clinical research in children with congenital heart disease (CHD) or pediatric acquired heart disease and adults with congenital heart disease (ACHD); to evaluate medical, interventional, and surgical therapies; and to serve as a clinical trials training ground for fellows, junior faculty and research nurses. Network studies are expected to emphasize diversity, equity, and inclusion, and to develop a more informed patient/family community and to earn the trust required to increase participation in PHN studies. The results of Network studies are expected to be widely disseminated and to improve the scientific basis of care for affected individuals.

The emphasis will be on clinical studies that will help to identify optimal therapies. The knowledge gained is expected to advance the development and application of novel therapies and treatment approaches.

Equipping pediatric cardiovascular researchers with the skills and experience needed to conduct multi-center clinical trials is essential to carry out the aims of the PHN. Funds for clinical research training have been included in this program. Ways in which funds will be allocated will be determined by the PHN leadership shortly after the start of funding under this FOA.

Funding Information


Estimated Total Funding

Up to $4,050,000 total costs for all 9 sites for FY2024

Expected Number of Awards


Estimated Award Ceiling

Up to $450,000 per award in FY2024

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Non-domestic (non-U.S.) Entity (Foreign Organization)

Applications are not being solicited at this time. 


Please direct all inquiries to:

Kristen Williams



D'Andrea Egerson

Gail Pearson