January 11, 2023
PA-20-272- Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
RFA-HL-24-004 - Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE) (R25 Clinical Trial Not Allowed)
RFA-HL-24-003 - Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE) Coordination Core (U24 Clinical Trial Not Allowed)
National Heart, Lung, and Blood Institute (NHLBI)
This Notice invites applications for administrative supplements to existing PRIDE Summer Institute (SI) programs to support program mentees in carrying out Small Research Projects (SRPs). Briefly, mentees in an active cohort will be eligible to be supported by their host PRIDE SI to conduct SRPs during or immediately following their first SI. These pilot studies are intended to be conducted over 9-12 months in the interim between the first and second SIs with guidance from SI and institutional mentors. Updates on projects are expected to be provided at the mid-year SI meetings, the consortium-wide PRIDE Annual Meetings, and/or during the mentee's second SI.
The NIH recognizes a unique and compelling need to promote diversity in the NIH-funded biomedical, behavioral, clinical, and social sciences workforce. The National Heart, Lung, and Blood Institute (NHLBI), part of the NIH, provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases, and sleep disorders and enhance the health of all individuals so that they can live longer and more fulfilling lives. The NHLBI expects efforts to diversify the workforce to lead to the recruitment of the most talented researchers from all groups, improve the quality of the educational and training environment, balance and broaden the perspective in setting research priorities, improve the ability to recruit subjects from underrepresented groups into clinical research protocols, and improve the Nation's capacity to address and eliminate health disparities.
The overarching goal of the Programs for Inclusion and Diversity among Individuals Engaged in Health-Related Research (PRIDE) program is to increase research independence among biomedical research scientists, including individuals from underrepresented groups (e.g., see NOT-OD-20-031), focused on heart, lung, blood, and sleep (HLBS) conditions. The program will be comprised of Summer Institutes (SIs) led by faculty mentors supported by RFA-HL-24-004, a Coordinating Core supported by RFA-HL-24-003, and the NHLBI Program Office. Each SI focuses on an area of science relevant to the NHLBI mission, and will conduct a 2-year mentoring program for 4 sequential cohorts of 6 to 12 mentee-scholars. The SIs work together with the Coordinating Core (CC) to establish mentor(s)-scholar teams which are matched based on common research interests. Mentors are recruited from the mentee-scholars' institutions, the SI’s sponsoring institution, and nationally, to complement the needed expertise for the mentees’ career goals. Mentees are selected via an application process managed by both the CC and the SI programs. Eligible candidates must have a doctoral degree, a faculty position upon matriculation, an early career status or new career focus, and protected time assured by their department chair or dean to participate in the program and conduct mentored research. In 2019, the PRIDE program added support for Small Research Projects (SRP) which enabled funding for pilot studies led by mentees participating in the summer institutes, intended to provide preliminary data to bolster a future grant application.
Proposed studies must focus on an NHLBI mission interest area or cross-cutting methodological area in an NHLBI area of scientific focus. As administrative supplements, the work proposed needs to be within the scope of the research or training that is already supported. Funds will be provided to perform additional research within the scope of the parent grant (i.e., aligned with the scientific focus of the R25 program) to help foster the research career development of the PRIDE mentee. Types of mentee research studies that can be supported by the SRP funds are limited to:
a) ancillary studies to an NIH-funded and registered clinical trial (no independent, NIH-defined clinical trial can be supported); and
b) independent, non-clinical trial research studies. These non-clinical trial research studies do not have to be attached to an NIH-funded study and can be qualitative/formative studies such as focus groups, interviews, surveys, observational study designs, etc., or basic science studies not involving humans.
Applicants will need to provide documentation of regulatory approvals/compliance as applicable to the proposed studies (e.g., Institutional Animal Care and Use Committee approval , institutional review board approval).
Only currently awarded PRIDE Summer Institute programs (R25) are eligible for this program. Mentees supported by the SI's SRP supplement must have an active appointment to the PRIDE program and have completed only the first summer institute at the time of application for the administrative supplement. Upon award of the SRP, mentees are expected to conduct their research during the interim between the first and second summer institute. Pending the timing of the SRP supplement award, it may be necessary for mentees to continue their research several months after the completion of the second summer institute (even if their formal appointment to the R25 has been terminated) in order to complete their award term.
The PRIDE Coordination Center will be expected to include the impact of SRPs as a part of the overall PRIDE program evaluation.
Before submitting an application, applicants are strongly encouraged to consult with the Program Official for the parent grant or the contact listed below to confirm eligibility and to obtain technical assistance.
Application and Submission Information
Applications for this NOSI must be submitted using the following opportunity or its subsequent reissued equivalent.
All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:
The progress report and budget for the supplement must be included with, but clearly delineated from, the progress report and budget for the parent award. The progress report must include information about the activities supported by the supplement even if support for future years is not requested.
NHLBI must be informed no later than 30 days of award termination. If the supplement has been in effect at least six months, a Final Progress Report must also be submitted.
Application Review Information
Administrative supplements do not receive peer review. Instead, the administrative criteria described below will be considered in the administrative evaluation process.
In coordination with the PRIDE CC, the NHLBI Program Staff will evaluate requests for a supplement to determine its overall merit. The following general criteria will be used to evaluate supplement applications:
Funding for supplement applications is not guaranteed. As with all supplement requests, a financial review to determine the need for additional funds will take place by the Office of Grants Management before a final funding decision is made.
Nicole Redmond, MD, PhD, MPH
National Heart, Lung, and Blood Institute (NHLBI)