Notice Number: NOT-HL-20-739
Key Dates
Release Date: April 16, 2020
Issued by
National Heart, Lung, and Blood Institute (NHLBI)
Purpose
The purpose of the Notice is to inform potential applicants that the National Heart, Lung, and Blood Institute (NHLBI) is participating, effective immediately, in PAR-20-097, "Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed)."
The following sections of PAR-20-097 have been updated to reflect the participation of NHLBI in this Funding Opportunity Announcement (FOA). Additions are italicized.
Part 1. Overview Information
Components of Participating Organizations
National Institute of General Medical Sciences (NIGMS)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute on Minority Health and Health Disparities (NIMHD)
National Cancer Institute (NCI)
National Heart Lung and Blood Institute (NHLBI)
Catalog of Federal Domestic Assistance
93.859; 93.393; 93.394; 93.395; 93.396; 93.399; 93.273; 93.279; 93.113; 93.307; 93.853; 93.840, 93.837, 93.838, 93.839, 93.233
Part 2. Full Text of Announcement
Section I. Funding Opportunity Description
Accessible, well-maintained, and efficiently operated data resources are critical enablers of modern biomedical research. Data resources, through good data management practices, are the key to data and knowledge discovery, integration, and data reuse, as outlined by the FAIR Data Principles (Findable, Accessible, Interoperable, and Reusable digital objects). In order to sustain a healthy and productive data resource ecosystem it is critical to ensure that each component: (a) delivers scientific impact to the communities that they serve; (b) employs and promotes good data management practices and efficient operation for quality and services; (c) engages with the user community and continuously addresses their needs; and (d) supports a process for data life-cycle analysis, long-term preservation, and trustworthy governance.
In order to better support such a modern data resource ecosystem, NIH makes a distinction between data repositories and knowledgebases. While each activity is important for advancing biomedical research, data repositories and knowledgebases can have unique functions, metrics for success and sustainability needs.
Biomedical knowledgebases have the primary function to extract, accumulate, organize, annotate, and link growing bodies of information related to core datasets, in compliance with the FAIR Data Principles. Biomedical data repositories on the other hand accept submission of relevant data from the community to store, organize, validate, archive, preserve and distribute the data, in compliance with the FAIR Data Principles. The funding announcement for biomedical data repositories is at PAR-20-089 .
This funding opportunity announcement supports the biomedical knowledgebases that are important to the mission of the NIH Institutes and Centers participating in this announcement. The evaluation of the repositories will empasize their utility and impact, quality of data and services and efficiency of operations, community needs and engagement, trustworthiness of stewardship and governance.
NHLBI Topics of Interest
NHLBI will support the development of biomedical data repositories (PAR-20-089) and knowledgebases (PAR-20-097) that will accelerate research on precision medicine, clinical decision support, imaging processing/imaging genomics, biological functional annotation of genomic variants, system biology and cellular pathway network modeling, systems science, social determinants, human-centered technologies, AI/machine learning/modeling, health disparities, global health, and implementation of clinical practice guidelines for heart, lung, blood, and sleep diseases. NHLBI will also support knowledgebases and data repositories that advance objective, contextual, and geographic measures that influence or predict the incidence, prevalence, and outcomes of heart, lung, blood, and sleep disorders and related social and environmental determinants. Validation of the impact and utility of the biomedical data repositories and knowledgebases in cardiovascular, pulmonary, blood, and sleep disease areas is required as appropriate.
Applicants are strongly encouraged to consult NHLBI Scientific Research Contacts regarding the appropriateness of the planned data resource application to the NHLBI mission, scientific areas of interests, and programmatic priorities. NHLBI-defined programmatic needs, and the NHLBI Strategic Vision inform support of resources, long-term funding needs, and sustainability plans of proposed data resources.
All other aspects of this FOA remain the same.
Inquiries
Please direct all inquiries to:
Scientific/Research Contact(s)
Rebecca A. Roper, MS, MPH
Center for Translation Research and Implementation Science
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-496-1051
Email: [email protected]
James Luo, PhD
Division of Cardiovascular Sciences
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0533
Email: [email protected]
Financial/Grants Management Contact(s)
Anthony Agresti
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-827-8014
Email: [email protected]
and Human Services (HHS)
