Notice Number: NOT-HL-18-657
Key DatesRelease Date: December 03, 2018
National Heart, Lung, and Blood Institute (NHLBI)
The Division of Blood Diseases and Resources within the National Heart, Lung, and Blood Institute (NHLBI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for the Physician Scientist Transition to Independence in Blood Science Research (R00 - Clinical Trial Optional) from physician scientist recipients of the K99/R00 Career Pathway to Independence in Blood Science Awards (RFA-HL-20-001 and RFA-HL-20-002).
This Notice is being provided in conjunction with the FOAs for the Career Pathway to Independence in Blood Science Awards for Physician Scientists (K99/R00) (RFA-HL-20-001 and RFA-HL-20-002). This Notice provides potential applicants to the K99/R00 program with information about the R00 award which is intended to provide physician scientists in blood science with a seamless pathway from mentored award to investigator independence. This NOITP allows potential eligible applicants sufficient time to develop competitive and responsive milestone-driven projects that will prepare the applicant for the timely submission of an R00 award and, subsequently, an R01 or equivalent application.
The limited competition FOA is expected to be published in August 2020 with an anticipated application due date beginning in Winter 2021.
This FOA will utilize the R00 activity code. Details of the planned FOA are provided below.
Research Initiative Details
Physician Scientist Transition to Independence in Blood Science Research (R00 Clinical Trial Optional) FOA to result from this NOITP:
The purpose of this limited competition R00 program is to provide physician scientists in blood science with a seamless pathway from a mentored K99/R00 award to investigator independence. Eligible applicants will have matriculated through the Career Pathway to Independence in Blood Science Awards for Physician Scientists ( K99/R00) program for up to three, but no more than five years. The strongest R00 applicants will propose an updated, well-conceived plan for 2–3 years of independent research support intended to prepare the applicant to subsequently compete for an R01 or equivalent award.
These research projects are limited to those that fall within the Division of Blood Diseases and Resources mission. The NIH encourages institutions to recruit and retain individuals from groups currently underrepresented in the biomedical sciences, and to enhance the diversity of the clinician-investigator workforce (NOT-OD-15-053).
R00 Award Budget: For the R00 award applicants may request directs costs up to $250,000 per year (to include NIH effort-commensurate salary cap) . Institutional indirect costs will be reimbursed at the extramural sponsoring institution’s indirect cost rate.
Eligible Individuals (Program Director/Principle Investigator)
Applicants who are eligible to respond to the limited competition R00 Funding Opportunity Announcement will have successfully completed the companion K99/R00 program. Physician scientists who successfully complete at least three years of the K99/R00 program, and who have been offered, and have accepted, an independent, tenure-track or equivalent faculty position, will be considered for up to 3 years of support to continue their research as independent clinician scientists.
Any physician scientist pursuing a career in non-malignant hematology with the skills, knowledge, and resources necessary to carry out the proposed research in blood science as the Program Director/Principal Investigator (PD/PI) is invited to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Multiple PDs/PIs are not allowed.
Candidates for this R00 award must have a health-professional doctoral degree. Such degrees include, but are not limited to, the MD, DO, MD/PhD, as well as MD-equivalent degrees. Candidates also must have completed their subspecialty training in hematology prior to receiving an award. However, candidates may submit an application prior to the completion of subspecialty training.
Level of Effort
At the time of award, the candidate must have a “full-time” appointment at the academic institution. Candidates are required to commit a minimum of 75% of full-time professional effort (i.e., a minimum of 9 person-months) to their program of career development during the mentored phase. Candidates may engage in other duties as part of the remaining 25% of their full-time professional effort not covered by this award, as long as such duties do not interfere with or detract from the proposed career development program.
Candidates who have VA appointments may not consider part of the VA effort toward satisfying the full-time requirement at the applicant institution. Candidates with VA appointments should contact the staff person in the relevant Institute or Center prior to preparing an application to discuss their eligibility. After the receipt of the award, adjustments to the required level of effort may be made in certain circumstances. See NOT-OD-09-036 for more details.
The applicant institution must have a strong, well-established record of research and career development activities and faculty qualified to serve as mentors in biomedical, behavioral, or clinical research in blood science. Institutional commitment must include space, facilities, resources, and other support needed to conduct the proposed research. The sponsoring institution must also provide protected research time (minimum of 75% effort) for the duration of the R00 award.
Estimated Total Funding $1,925,000
Expected Number of Awards 5
Estimated Award Ceiling $385,000
Primary CFDA Numbers 93.839
Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
Indian/Native American Tribal Government (Federally Recognized)
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Applications are not being solicited at this time.
Please direct all inquiries to:
Lisbeth Welniak, PhD
National Heart, Lung, and Blood Institute (NHLBI)