Notice Number: NOT-HL-18-656
Key DatesRelease Date: October 17, 2018
The purpose of this Notice is to inform potential applicants that the National Heart, Lung, and Blood Institute (NHLBI) andNational Institute on Drug Abuse (NIDA) intend to publish a new Funding Opportunity Announcement (FOA) that will support basic research to elucidate mechanistic interactions between sleep and circadian activity and opioid use that impact on vulnerability to opioid use disorder.
This Notice is being provided to allow potential applicants time to develop necessary collaborations and appropriate applications. The FOA is expected to be published in November 2018, with an expected application due date in February 2019.
This FOA will utilize the R01 (Clinical Trial Not Allowed) mechanism and will be an RFA. Details of the planned FOA are provided below.
Research Initiative Details
The intended FOA will invite applications to elucidate sleep and circadian mechanisms closely-coupled to mechanisms of opiod use disorder (OUD), particularly mechanisms that determine the severity of physical dependence, addiction, propensity to relapse and that modify responses to medication-assisted therapy (MAT). Identifying mechanisms by which sleep and circadian activity contributes to these aspects of OUD and conversely how sleep and circadian rhythm are affected during the trajectory of opioid use and recovery addresses a knowledge gap and can present new opportunities for improved therapy and outcome. Multi-disciplinary, multiple-investigator teams of basic researchers combining expertise in mechanisms of sleep/circadian rhythms, the neurobiology of OUD and neuropharmacology of MAT are strongly encouraged. This FOA is only open to the study of OUD relevant mechanisms. The study of other drugs of abuse will not be responsive. Projects developed for this program should contribute significantly to the NIH HEAL (Helping to End Addiction Long-term) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis.
Estimated Total Funding NHLBI intends to commit total costs up to $2,000,000 in FY2019.
Expected Number of Awards NHLBI intends to support up to 4 awards in FY2019.
Estimated Award Ceiling Application budget direct costs may not exceed $300,000 per year.
Primary CFDA Numbers 93.233, 93.838, 93.838, 93.839, 93.279
Anticipated Eligible Organizations
Please direct all inquiries to: