Request for Information (RFI): NHLBI R35 Programs

Notice Number: NOT-HL-18-614

Key Dates
Release Date: April 2, 2018
Response Date: April 18, 2018

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The goal of this Request for Information (RFI) is to solicit comments and experiences to guide the development and implementation of the NHLBI R35 Funding Opportunity Announcement (FOA) renewal.


In December 2015, the NHLBI released the Emerging Investigator Award (EIA) and Outstanding Investigator Award (OIA) R35 programs. The purpose of the programs is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors /Principal Investigators (PDs/PIs) who are currently PDs/PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrate their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The NHLBI R35s support research programs, rather than research projects. The R35 funding is the primary and in most cases sole source of NHLBI funding, and support the HLBS research for up to seven years with increased flexibility to conduct ground breaking research, extend previous discoveries in new directions, and allow PDs/PIs to take greater risks and pursue research that requires a longer timeframe.

Information Requested

The NHLBI is interested in the following information to guide the R35 FOAs renewal:
  1. If you applied for the NHLBI R35 program, describe the features of the program that encouraged you to apply. If you did not apply, describe the factors that discouraged you from applying. Describe changes that would encourage one to apply to a future R35 program.
  2. Describe how the NHLBI R35 has had an impact on:
    1. your scientific productivity and your time spent on research activities (including mentoring junior scientists, performing scientific research, etc.),
    2. your ability to be flexible with research directions and/or ideas as they arise,
    3. your administrative burden.
  3. Provide other comments, suggestions, or considerations to enhance the NHLBI R35 program.

How to Submit a Response

All responses must be submitted electronically as follows:
  • Reply on or before April 18, 2018
  • Place NHLBI R35 RFI in the subject line of the email response
  • Email to
Responses to this RFI Notice are voluntary. Submitted information will not be considered confidential. Responses are welcome from associations and professional organizations as well as individual stakeholders. This RFI is for planning purposes only and should not be construed as a solicitation or as an obligation on the part of the Federal Government, the National Institutes of Health, or individual NIH Institutes or Centers. The NIH will use the information submitted in response to this RFI at its discretion. The information submitted will be analyzed and may be shared internally, appear in reports or be reflected in future solicitations, as appropriate and at the Government’s discretion. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information provided and will not provide feedback to respondents.


Please direct all inquiries to:

Narasimhan Danthi, Ph.D.
Division of Cardiovascular Sciences
Telephone: 301-451-5170

Lisa Postow, Ph.D.
Division of Lung Diseases
Telephone: 301-827-7843

Andrei Kindzelski, Ph.D.
Division of Blood Diseases and Resources
Telephone: 301-827-8275

Emmanuel Peprah, Ph.D.
Center for Translation Research and Implementation Science
Telephone: 301-496-3620