Notice Number: NOT-HL-18-606
Key DatesRelease Date: March 16, 2018
National Heart, Lung, and Blood Institute (NHLBI)
The National Heart, Lung, and Blood Institute intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications from qualified institutions willing to participate with NHLBI in the Cardiothoracic Surgical Trials Network (CTSN) as Linked Clinical Research Centers (LCRCs). ?This revised Notice replaces NOT-HL-18-588 to alert the scientific community to a critical change to the inclusion criteria to include affiliate sites in the submission. The mechanism has also beenchanged from a U10 to UM1. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and appropriate projects.
The FOA is expected to be published in May 2018 with an expected application due date in July 2018.
This FOA will utilize the UM1 activity code (https://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=UM1%20). Details of the planned FOA are provided below.
Research Initiative Details
This Notice encourages investigators with expertise and insights into the area of Cardiac Surgery to begin to consider applying for this new FOA.
The LCRCs will: (1) conduct collaborative randomized controlled trials (RCTs) and studies that evaluate cross specialty team-based care, interventions and novel therapies in the context of cardiac surgery but with broader relevance to cardiology and neurology; (2) utilize these findings to improve patient outcomes, and influence clinical practice, with benefits that are translatable to the general population; (3) conduct implementation research alongside RCTs to understand the best strategies for optimal uptake and sustainability and to bolster translation in areas of high disease burden; and (4) foster the next generation of clinical and implementation researchers.
To achieve budget efficiencies, while at the same time enhancing the output and scope of the enterprise, the CTSN infrastructure will be slightly changed to include a new clinical research paradigm of paring experienced academic cardiac surgical clinical research centers with currently less experienced academic clinical research centers in high disease burden areas in the form of a Multi-PI grant application, the Linked Clinical Research Centers (LCRCs). A total of 5 LCRCs are proposed with the awards made to high quality established academic cardiothoracic surgery programs with a track record of successful participation in RCTs that will incorporate a second academic cardiac surgical site with less clinical research experience. Less experienced academic cardiac surgical sites should show fewer than 3 NHLBI RCT trials conducted in cardiac surgery and less than $3 Million in NHLBI total grant funding to the institution in 2017. The less experienced academic cardiac surgical site should be one that would benefit from research mentoring and a collaborative clinical research opportunity, and is located in a high cardiovascular disease- burdened part of the country to build capacity in this area. A high CV disease burden area is broadly defined as an area or region of the United States or Canada that has a preponderance of cardiovascular disease including hypertension, obesity, diabetes, and stroke, or some other unique disease burden characteristic. These areas might include the Geographic regions incorporating the Mississippi Delta, Appalachia, Stroke Belt (South East United States (US)), Stroke Buckle (coastal plains areas of the Carolinas and Georgia), Newfoundland/Labrador (Canada), rural or inner-city locales, or involve predominantly minority or low SES populations. Institutional funding can be verified through the use of the NIH Research Portfolio Online Reporter Tools (RePORTER) located at https://report.nih.gov/award/index.cfm?ot=&fy=2017&state=NH,WV&ic=NHLBI&fm=&orgid=&distr=&rfa=&om=n&pid=&view=statedetail.
This enhanced platform will be further used to develop the next generation of clinical and implementation researchers. Each LCRC application will also contain an application for a Clinical and Implementation Research Skills Program (CIRSP). These skills programs will be encouraged to include underrepresented minorities to address needed diversity within the cardiac surgical clinical research workforce with the potential to transition into research leadership roles. The clinical and implementation research scholars will be developed to expand skills and knowledge that can then be transported to academic and clinical programs when the junior clinical investigators complete their skills development.
Applications from the NHLBI-funded Core Clinical Centers (CCCs) and Consortium Centers will be evaluated in addition to applications from institutions not presently in the CTSN, with the requirement of the described site linkage and inclusion of a Clinical and Implementation Research Skills Program.
Estimated Total Funding $3,200,000
Expected Number of Awards 5
Estimated Award Ceiling $400,000 (Direct Costs)
Primary CFDA Numbers 93.837
Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
Indian/Native American Tribal Government (Federally Recognized)
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Applications are not being solicited at this time.
Please direct all inquiries to:
Marissa A. Miller, DVM, MPH
National Heart, Lung, and Blood Institute (NHLBI)