This Notice was RESCINDED on March 23, 2018, please see NOT-HL-18-610 that replaces it.


RESCINDED - NHLBI Only Accepts Clinical Trial Applications Proposing Mechanistic Studies for the NIH Parent R01 Clinical Trial Required Announcement

Notice Number: NOT-HL-17-546

Key Dates
Release Date: November 3, 2017 (Rescinded - March 23, 2018)

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The purpose of this Notice is to inform potential applicants that NHLBI will only accept mechanistic studies that meet NIH’s definition of a clinical trial in response to PA-18-345 NIH Research Project Grant (Parent R01 Clinical Trial Required) and its reissues. A mechanistic study is designed to understand a biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention.

If the proposed research project includes a clinical trial other than a mechanistic study, applicants are strongly advised to contact NHLBI staff to determine the appropriate alternative NHLBI-specific clinical trial FOAs.


Please direct all inquiries to: