Notice of Intent to Publish a Funding Opportunity Announcement for Heart, Lung, and Blood Co-morbiditieS Implementation Models in People Living with HIV (HLB SIMPLe) (U01)

Notice Number: NOT-HL-17-520

Key Dates
Release Date: June 19, 2017

Estimated Publication Date of Announcement: Winter 2017
First Estimated Application Due Date: Spring 2018
Earliest Estimated Award Date: Winter 2018
Earliest Estimated Start Date: Winter 2018

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The National Heart, Lung, and Blood Institute intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for late-stage (T4) translation research into the delivery of proven effective interventions and treatments for heart, lung, blood, and sleep (HLBS) co-morbid disorders in people living with HIV (PLWHIV) in World Bank-defined Low- and Middle-Income Countries (LMICs) and Small Island Developing States (SIDS), as traditionally defined by the World Health Organization. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in Winter 2017 with an expected application due date in Spring 2018. Additionally, see Notice NOT-HL-17-521 for more information pertaining to the associated HLB SIMPLe Data Coordinating Center (U24).

This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

The intended FOA will solicit applications that propose late-stage translation (T4) research to facilitate the translation and uptake of proven effective interventions and/or therapies to prevent or mitigate the impact of HLBS comorbid conditions in PLWHIV in LMICs and SIDS. This initiative will support collaborative research teams composed of multidisciplinary partners (e.g., public health researchers, policy makers, Ministries of Health, academic and health system delivery researchers, community collaborators, and others) to conduct locally or regionally identified high-priority implementation research in real-world settings. Awards made through this FOA will support up to 5 years of project-related activities.

The purpose of this initiative is to utilize implementation research models and strategies to address barriers that impede the scale-up and efficient application of proven effective interventions in community and clinical settings for the prevention, control, and treatment of comorbid HLBS conditions in PLWHIV in LMICs and SIDS. The focus is on implementation science within the late-stage T4 translation research phase, which is defined as research that identifies implementation strategies to enhance sustainable uptake of proven effective interventions into real world settings. Research outcomes include acceptability, affordability, and appropriateness of interventions as well as feasibility, fidelity, penetration, and sustainability of the intervention in the specific context.

Applicants are encouraged, but not required to use a multiple program director/principal investigator (PD/PI) mechanism to facilitate collaborations between HIV and HLBS implementation science investigators, LMICS and SIDS researchers, along with community, governmental and non-governmental collaborators.



Please direct all inquiries to:

LeShawndra Price, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-496-1051