Notice Number: NOT-HL-17-484

Key Dates
Release Date: January 27, 2017

Estimated Publication Date of Announcement: April 2017
First Estimated Application Due Date: July 2017
Earliest Estimated Award Date: February 2018
Earliest Estimated Start Date: March 2018

Issued by
National Heart, Lung, and Blood Institute (NHLBI)

Purpose

The National Heart, Lung, and Blood Institute (NHLBI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) which will support studies that utilize cross-disciplinary science and novel technologies to define the basic mechanisms involved in the development of anti-factor VIII (FVIII) neutralizing antibodies, also known as FVIII inhibitors, in patients with congenital hemophilia A.

This Notice is being provided to allow potential applicants sufficient time to develop application.
The FOA is expected to be published in April 2017 with anticipated application receipt dates in July 2017.

This FOA will utilize the U54 activity code. Details of the planned FOA are provided below.

Research Initiative Details

The intended FOA will seek applications that propose to establish Research Centers of Excellence with the aim of investigating and definitively elucidating the mechanistic and translational mechanisms involved in the formation, suppression and/or elimination of anti-FVIII antibodies. Investigators will be encouraged to apply novel, interdisciplinary, bold new approaches to defining FVIII protein-specific triggers and mechanisms underlying the development of anti-FVIII neutralizing antibodies. In addition to the currently active scientific disciplines in this field (biochemistry, immunology, molecular biology, genetics), Centers will be required to include emerging sciences and technologies not currently being exploited in this research area (e.g., microbiology, glycobiology, biophysics, computational biology, in silico chemistry), in proposed research projects.

The FOA will also seek to leverage the scientific expertise assembled at these Research Centers to support the cross-training of the next generation of physicians/scientists with interdisciplinary research skills applicable not only to the field of hemostasis, but across the entire spectrum of blood sciences.

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Ronald Warren, PhD
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: (301) 827-8288
Email: ronald.warren@nih.gov

Malgorzata Klauzinska, PhD
The National Heart, Lung, and Blood Institute (NHLBI)
Telephone: (301) 827-8276
Email: malgorzata.klauzinska@nih.gov

Donna DiMichele, MD
The National Heart, Lung, and Blood Institute (NHLBI)
Telephone: (301) 435-0063
Email: donna.dimichele@nih.gov