Notice of Correction to Application and Submission Information for PAR-16-402 "NHLBI Program Project Applications (P01)"

Notice Number: NOT-HL-16-446

Key Dates
Release Date: September 30, 2016  

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


On August 15, 2016, the NHLBI issued Funding Opportunity Announcement PAR-16-402 "NHLBI Program Project Applications (P01)".  The purpose of this Notice is to inform applicants that requests for direct costs of $500,000 or more in any year are required to follow the following instructions:

Part 2. Section IV. Application and Submission Information

7. Other Submission Requirements and Information


Requests of $500,000 or more for direct costs in any year

Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact a Scientific/ Research Contact at least 6 weeks before submitting the application and follow the Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the SF424 (R&R) Application Guide. Applicants to this FOA must also:

1. Discuss the proposed Program Project Grant application with NHLBI program, review, and grants management staff via an in-person meeting or a conference call (i.e., staff consultation). Potential applicants are strongly encouraged to begin informal discussions with NHLBI scientific staff as early as possible in the process of planning their proposed research application, but no less than 10 weeks prior to the submission deadline. The staff consultation: (1) ensures that the NHLBI receives applications that are scientifically aligned with the Institute’s mission and strategic vision and (2) enables the Institute to consider the budgetary impact of supporting such a Program.

2. Submit a letter of request to the NHLBI. After the staff consultation, the intended applicant(s) submit a letter of request (as a PDF attached to an email) to the Director of the NHLBI extramural Program Division whose research mission is most relevant to the proposed topic (Scientific/ Research Contact). This letter serves as the formal request seeking permission to submit an application with direct costs of $500,000 or more in any one year.

3. Obtain written agreement from NHLBI that the Institute will accept the application for consideration for award.

4. Applicants must include a cover letter with the application that identifies the NHLBI Program staff member(s) with whom they have been in contact regarding the application along with a copy of the written agreement letter from NHLBI. If the Subtotal Direct Cost on the cover page of the application exceeds the amount the NHLBI agreed to accept, the application may be withdrawn or not awarded.

The instructions in this section apply to all new, renewal, or resubmission applications, with the exception that renewal and resubmission applications do not need to obtain the staff consultation indicated in item 1.

All other aspects of this FOA remain unchanged.


Please direct all inquiries to:

Melissa Nagelin, Ph.D.
National Heart, Lung and Blood Institute (NHLBI)
Telephone: 301-594-8518