Request for Information (RFI) Regarding Opportunities to Advance Clinical Research in Heart Failure

Notice Number: NOT-HL-16-319

Key Dates
Release Date: May 18, 2016
Response Date: June 18, 2016

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The National Heart, Lung, and Blood Institute (NHLBI) seeks input from members of the heart failure community about opportunities, appropriate infrastructure, critical needs, and key questions that will advance research in order to optimize the care and treatment of individuals with heart failure. NHLBI invites comments from researchers, patient advocacy groups, patients, and healthcare providers.

Background Information

NHLBI currently supports the Heart Failure Clinical Research Network, which provides a platform for collaborative clinical research in heart failure, to improve our understanding of the condition and to test therapeutic treatments. NHLBI is particularly interested in understanding how its investment in heart failure research can be maximized for future challenges and whether the current network configuration could be improved to better address key scientific priorities.

Information Requested

This RFI is intended to solicit perspectives and comments from the broad community on scientific opportunities, critical needs, and optimal configurations for conducting research in heart failure. Comments may include but are not limited to the following concerns:

1. The most important questions and gaps in knowledge in the field that need to be answered over the next 5-10 years.
2. Programs, investments, and/or grant mechanisms that NHLBI should employ to foster basic, translational, and clinical research in heart failure, and how these programs or investments should be configured to best address the important questions in the field.

Your comments can be submitted anonymously. If you choose not to identify yourself when replying, please identify your role in the field to help us better understand the thoughts of particular groups. For example, please indicate if you are a heart failure care provider, patient, caregiver, patient advocate, heart failure researcher, etc.


To ensure consideration, all responses should be submitted by June 18, 2016.
Please respond by e-mail to: and include the text “RFI Reply” in your subject line.


Responses to the RFI are voluntary and may be anonymous. Any identifiers (e.g., names, institutions, e-mail addresses, etc.) will be removed when responses are compiled. Only the processed, anonymized results will be shared internally with scientific working groups convened by the NIH, as appropriate. Proprietary, classified, confidential, or sensitive information should not be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s). 

This request is for information and planning purposes only and should not be construed as a solicitation or as an obligation on the part of the United States Government. Neither the NHLBI nor the NIH will make any awards based on responses to this RFI, nor will the NHLBI or the NIH otherwise pay for the preparation of any information submitted or for the Government's use of such information.
The NHLBI will use the information submitted in response to this RFI at its discretion and will not provide comments to any responder's submission. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).


Please direct all inquiries to:

Emily Tinsley, MS
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0519