Notice of Intent to Publish a Funding Opportunity Announcement for Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC) (UM1)

Notice Number: NOT-HL-12-155

Key Dates
Release Date: October 10, 2012
Estimated Publication Date of Announcement:  November 14, 2012 
First Estimated Application Due Date:  February 6, 2013 
Earliest Estimated Award Date:  December 1, 2013 
Earliest Estimated Start Date:  December 1, 2013 

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The National Heart, Lung, and Blood Institute intends to promote a new initiative by publishing a  Funding Opportunity Announcement (FOA) to solicit applications for research on trauma-induced coagulopathy (TIC).  The purpose of the Trans Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC) FOA is to support a single multi-component basic collaborative Research Program to conduct a hypothesis-driven study of trauma-induced coagulopathy. Through this initiative, the National Heart, Lung and Blood Institute and the Department of Defense (DoD) are in partnership to form a consortium with the Research Program to address TIC by linking clinical investigators involved with ongoing DoD funded trauma-related clinical trials with the Research Program scientists who will have the unique opportunity to utilize patient samples in their basic research in TIC.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Fall 2012 with an expected receipt date in Winter 2013.

This FOA will utilize the UM1 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages the collaboration of investigators with expertise and insights into coagulation, inflammation and vascular biology to begin to consider applying for this new FOA.

The proposed TACTIC RFA intends to fund a single multi-component Research Program that will become part of an NHLBI-DoD consortium to address multiple research aspects of TIC.  Under this FOA, the NHLBI invites a multidisciplinary team, led by single or multi-PI investigators, to establish innovative basic research collaborations to support hypothesis-driven research in TIC utilizing samples that reflect early, pre-hospital development and evolution of coagulopathy in patients with severe trauma.  Through the Consortium, investigators will have access to patient samples from DoD-supported trauma trials at Level I Trauma Centers and data exchange with the DoD Systems Biology Program in TIC. The objective of the TACTIC program is to support a hypothesis-driven basic research study of the pathophysiological mechanisms underlying TIC and to translate emerging mechanistic data into new early diagnosis and effective treatment strategies for TIC.



Please direct all inquiries to:

Andrei L. Kindzelski, M.D., Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0070

Weekly TOC for this Announcement
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