RFP Announcement: Coronary Artery Risk Development in Young Adults (CARDIA) Study - Coordinating Center, Field Centers, and Echocardiography Reading Center

Notice Number: NOT-HL-12-149

Key Dates
Release Date: August 17, 2012

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


As part of the Coronary Artery Risk Development in Young Adults (CARDIA) Study renewal, the National Heart, Lung, and Blood Institute (NHLBI) plans to solicit proposals from qualified organizations to establish:

*   one (1) Coordinating Center
*   four (4) Field Centers
                 Oakland, CA Field Center
                 Chicago, IL Field Center
                 Minneapolis, MN Field Center
                 Birmingham, AL Field Center
*   one (1) Echocardiography Reading Center

The RFPs can be accessed through the FedBizOpps (URL: https://www.fbo.gov/) or through the NHLBI website at the following address: URL: http://www.nhlbi.nih.gov/funding/inits/index.htm#rfp.  The electronic RFPs contain all information needed to submit a proposal.

Research Initiative Details

CARDIA began in 1985 in four U.S. communities (Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA). The original cohort (n=5,115) was selected to have approximately the same number of participants in subgroups of age (18-24 and 25-30), sex, race (black and white), and education (high school or less and more than high school) within each community. Seven additional examinations have been completed every 2-5 years, including a Year 25 examination completed in 2011.

The objectives of the renewal of the CARDIA program are: (1) to perform a limited examination of the cohort to determine abnormalities in cardiac structure and function that exist in a community-based sample of mid-to-late middle-aged adults; to utilize novel measures to better understand myocardial dysfunction; to examine 25-year trajectories in cardiac structure and function; and to assess whether these abnormalities and trajectories differ between white and black adults; (2) to continue cohort follow-up for cardiovascular events, including heart failure, coronary heart disease, stroke, and atrial fibrillation; and (3) to provide a platform for ancillary studies particularly to the cohort examination, a training ground for new investigators, and support data sharing. These objectives will be accomplished through annual follow-up and a ninth (Year 30) examination of the existing cohort.

Potential offerors are responsible for downloading the RFP and any attachments. It is also the offerors' responsibility to monitor the FedBizOpps web page for the release of any amendments to the RFP. Interested parties must respond to the solicitation in order to be considered for award of any resultant contract. This acquisition has been designated as a full and open competition under the North American Industry Classification System (NAICS) code 541712. Subcontracting opportunities are anticipated during the course of this contract award.

Awards for the CARDIA study are anticipated to be made on or around July 1, 2013. The CARDIA study involves a limited examination (Year 30) of the cohort in June 01, 2015 thru May 31, 2016; as well as continued follow-up contact and clinical events surveillance of the cohort. Efforts for the Coordinating Center, the Field Centers and the Echocardiography Reading Center are expected to begin on July 01, 2013 and to end on June 30, 2018.


Please direct all inquiries to:

Elizabeth Zoller, Contract Specialist
National Heart, Lung and Blood Institute
6701 Rockledge Drive
Bethesda, MD 20876

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