Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network (U10)

Notice Number: NOT-HL-10-107

Update: The following update relating to this announcement has been issued:

Key Dates
Release Date:  May 7, 2010

Issued by
National Heart, Lung, and Blood Institute (NHLBI), (


The National Heart, Lung, and Blood Institute (NHLBI) intends to issue a  Funding Opportunity Announcements (FOA) titled: “Blood and Marrow Transplant Clinical Trials Network (BMT CTN) – Core Clinical Centers (U10)” .  The goal of this initiative is to support a cooperative, multicenter clinical program that promotes efficient comparison of novel treatment and management approaches for the potential benefit of children and adults undergoing hematopoietic stem cell transplantation.  Core Clinical Centers are expected to identify areas of scientific need, and to develop and participate in new Phase II and Phase III clinical trials designed to improve transplant outcomes and change clinical practice.  The Data Coordinating Center is expected to bring scientific, technical, and administrative expertise for the full range of activities needed to support the conduct of new multicenter trials in hematopoietic stem cell transplantation. The Data Coordinating Center will manage protocol dollars for all sites enrolling subjects on BMT CTN trials. 

The FOA for the Core Clinical Centers is anticipated to utilize the U10 NIH Cooperative Clinical Research Center Agreement grant mechanism.  The funds awarded and the number of awards will depend on the number, quality, duration, and costs of the applications received. A companion FOA is expected to be published for Data Coordinating Center applications (see NOT-HL-10-108). 

This FOA is expected to be published in the summer of 2010 with applications due in the fall of 2010.

This Notice is being provided to allow potential applicants sufficient time to develop responsive projects. 



Interested parties may contact:

Nancy L. DiFronzo, Ph.D.
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute
6701 Rockledge Drive
Bethesda MD 20892-7952
Bethesda, MD 20817 (for courier service)
Telephone: 301-435-0065
Fax: 301-480-1046


Roy Wu, Ph.D.
Chief, Clinical Grants and Contracts Branch
Cancer Therapy Evaluation Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
6130 Executive Boulevard
EPN 7009
Bethesda, Maryland 20892
Rockville, Maryland (FEDEX) 20852
Telephone:  301-496-8866
Fax:  301-480-4663

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