Notice of Intent to Issue an RFA to Support an NHLBI Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine

Notice Number: NOT-HL-06-122

Key Dates
Release Date: February 21, 2006

Issued by
National Heart, Lung, and Blood Institute (NHLBI), (

The purpose of this Notice is to announce the intention to issue a Request for Applications (RFA) in early 2006 to support a network of academic centers with clinically active cardiothoracic surgeons and their colleagues in allied specialties to evaluate newer techniques, technologies, devices and innovative pharmaceutical and bioengineered products in cardiovascular surgical practice. This will be accomplished through an infrastructure for multicenter collaborative clinical research. The receipt date for applications would be in the late summer of 2006.

The primary goal of the network is to conduct multiple, collaborative, proof-of-concept, clinical protocols to evaluate surgical and minimally invasive interventional strategies to improve the treatment of cardiovascular disease in adult populations. It is anticipated that the Network would conduct relatively small, short-term clinical studies. Clinically important surrogate endpoints should be considered in the design of studies that are both economical and of short duration, yet further the translation of new therapies, procedures, and technologies to clinical practice. This Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine will ensure that the public has access to the best procedures determined by careful assessment.

Results of the network studies are expected to be widely disseminated, to improve the scientific basis of care for affected individuals, and to serve to inform future larger clinical trials. The Network will also serve as a clinical trials training ground for fellows and junior faculty.

This Notice is to encourage investigators who believe that they have sufficient expertise to begin considering applying for this RFA program.


Interested parties may contact:

Marissa A. Miller, DVM, MPH
Division of Heart and Vascular Disease
National Institutes of Health
6701 Rockledge Drive
Room 9180, MSC 7940
Bethesda , MD 20892-7940
Telephone: (301) 594-1542
FAX: (301) 480-1336

Weekly TOC for this Announcement
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