Notice of the NHLBI Program on Genome-Wide Association Studies to Identify Genetic Components that Relate to Heart, Lung, and Blood Disorders

Notice Number: NOT-HL-06-114

Key Dates
Release Date: January 10, 2006

Issued by
National Heart, Lung, and Blood Institute (NHLBI), (

The purpose of this Notice is to announce the intention to issue a Request for Applications (RFA) in early 2006 to support genome-wide association studies to identify genetic components related to heart, lung, blood (HLB) disorders and their risk factors using existing population, family and clinical studies.

This FOA will support innovative strategies for genome-wide association studies in existing population, cohort, clinical and family studies. Studies may seek to identify associations of genes with the presence of one particular HLB disorder and may examine interactions among genetic and environmental factors; susceptibility for multiple conditions; or associations of genes with disease risk factors, disease incidence, or therapeutic responsiveness. A diversity of participant populations regarding age, sex, and race/ethnicity will be supported under this initiative. Investigators should have access to existing sources of DNA from such population studies. Funding will be provided for genotyping and data analysis. This solicitation will fund measurement of genomic data on available samples from existing human studies and analysis of those data. No recruitment, additional phenotyping, or sample acquisition will be supported by this RFA.

The data generated by this effort will contribute to our knowledge of the underlying biochemical pathways to disease, the interaction of genetic components with each other and with the environment. Results have the potential to identify novel predictors of disease, new therapeutic interventions, prevention strategies and treatments, as well as predictors of response to treatment.

This Notice is to encourage investigators who believe that they have sufficient expertise and access to existing DNA specimens and phenotypic data from an existing human population-, clinic-, or family-based study to begin considering applying for this RFA program.



Interested parties may contact:

Cashell E. Jaquish, Ph.D.
Division of Epidemiology and Clinical Applications
National Institutes of Health
6701 Rockledge Drive
Room 8170, MSC 7934
Bethesda, MD 20892-7934
Telephone: (301) 435-0447
FAX: (301) 480-1455

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