Release Date:  August 11, 2000

NOTICE:  HL-01-002

National Heart, Lung, and Blood Institute


Heart, lung, blood, and sleep disorders are complex human conditions that, 
until recently, have been viewed from the perspective of only one or a few 
genes operating at a time.  With the progress of the Human Genome Project, we 
will soon be able to examine all human genes simultaneously and attempt to 
relate them to research questions relevant to heart, lung, blood, and sleep 
disorders.  A key tool in this endeavor will be microarray technology.


The challenge before the National Heart, Lung, and Blood Institute (NHLBI) is 
to determine the most appropriate, effective, and timely strategies to 
address the needs, facilitate the opportunities, and minimize the obstacles 
in fully developing and applying array technologies to heart, lung, blood and 
sleep research  Thus, the NHLBI is soliciting input from the scientific 
communities that it serves to guide in the development of these strategies.


The NHLBI is requesting that you send us your thoughts, opinions, and 
suggestions in each of the key areas described below [each is defined by a 
keyword(s)].  Responses may be sent through the online form 
(http://www.nhlbi.nih.gov/resources/medres/rfinote.htm), by letter, email, or 
fax to the address listed below by September 1, 2000. 


You may have encountered significant barriers to gaining access to microarray 
technology.  The NHLBI would like to hear your comments, views, and opinions 
on barriers to access (e.g., technology, resources, or other) and on barriers 
to optimal use of microarrays (e.g. lack of expertise, financial limitations, 
or other).  If you are currently using microarrays in your research, please 
describe how you overcame barriers to access in applying microarray  
strategies to your research. 

NHLBI is currently studying ways in which it can increase the base of 
participation in microarrays.  Your thoughts are welcome on the best ways to 
facilitate access to microarray technology in the heart, lung, blood and 
sleep research communities  Examples could include a grant supplement program 
for microarray implementation in ongoing programs, a resource facility that 
would make and distribute custom chips of interest to the NHLBI community, a 
program directed toward technology development, a program to support local or 
regional chip development and distribution, or an expanded effort as 
facilitator to bring together investigators with common interests so as to 
share costs.
There is universal agreement that good bioinformatics and information 
resources are essential tools for the optimal use of high-throughput gene 
analysis methods such as microarrays. Your suggestions for the best ways for 
NHLBI to help develop and disseminate these tools are welcome. 

The NHLBI is interested in your assessment of the overall needs and research 
opportunities that microarray access and application afford that cannot be 
addressed by other means.  Any specific suggestions, and general estimates of 
associated costs, for how NHLBI can meet these needs would be valuable. 

We would appreciate any additional thoughts or comments that you think would 
be useful.

Thank you for your help.

We look forward to your input and please  share this document with your 

To respond, please send a letter, fax or email to the following address or 
link to the online form in the What’s New section on the NHLBI Home Page.

Ms. Tawanna Meadows
Two Rockledge Centre
6701 Rockledge Drive
Room 9163, MSC 7940, 
Bethesda,  Maryland 20892-7940
FAX (301) 480-1335
Phone (301) 435-1802
Email: array@nhlbi.nih.gov 


Overcoming Barriers

Facilitating Access

Bioinformatics and Information Resources

Overall Needs and Research Opportunities 


Additional Thoughts or Comments

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