October 11, 2023
National Human Genome Research Institute (NHGRI)
The National Human Genome Research Institute (NHGRI) is issuing this Notice of Special Interest (NOSI) to seek Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications in the field of genomic medicine. Specifically, NHGRI seeks applications to research and develop innovative solutions with commercial potential, such as new clinical services, computer software, mobile apps, and other products, that enable the use of genomic information in clinical care for individuals of all racial/ethnic backgrounds and socioeconomic statuses. Applications should focus on genomic medicine, defined as the utilization of an individuals genomic information as an integral part of their clinical care (e.g., for screening, diagnostic, or therapeutic decision-making) while improving health outcomes and addressing policy implications of that clinical use.
NHGRI supports small businesses that develop services and products that can be used across a broad spectrum of diseases. Applications may focus on a particular disease or organ system as an exemplar if the generalizability to multiple diseases is explained. Applications that are not generalizable should be directed to the appropriate Institute or Center. Similarly, projects that focus only on a gene or limited set of genes will not be appropriate for NHGRI funding unless broad applicability is clearly explained, potential for the approach to eventually scale to be genome-wide is demonstrated, and use of a single gene or limited set of genes is well justified. All applications, regardless of focus, should explain how generalizable, broadly useful, and transformative their approaches will be to the field of genomic medicine.
NHGRI Small Business Program
The NHGRI Small Business Program participates in the NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. In general, the NHGRI Small Business Program is interested in supporting small businesses that engage in the research and development of innovative technologies that improve health through work in the field of genomics and have a strong potential for commercialization.
Genomic Medicine Research
The past decade has seen a significant growth in the implementation of genomics in clinical practice. NHGRI has primarily funded genomic medicine research through multi-disciplinary consortia and investigator-initiated research. This funding opportunity is intended to stimulate technological innovation and encourage small businesses to engage in research and development in the field of genomic medicine.
This NOSI centers on stimulating the research and development of promising technologies and products necessary to use genomic information in clinical care. The following are examples of topics on which small businesses could focus, but are not exclusive, grouped by category:
Implementing genomic medicine
Facilitating analysis of clinical genomic data
The pace and volume of genomic data being generated presents challenges and opportunities for solutions and tools that facilitate clinical analysis.
Improving clinical access and sharing of genomic data
Clinical access and sharing of genomic data is critical to promoting genomic medicine.
Small businesses funded though this NOSI will be considered to be part of the Advancing Genomic Medicine Research (AGMR) Program. Thus, awardees will be encouraged to attend an annual AGMR grantee meeting hosted by NHGRI. These annual meetings serve as venues to facilitate sharing of research findings; promote the exchange of ideas; enable discussion of opportunities, challenges, and emerging needs; develop expertise and abilities among collaborators newer to genomic medicine; and accelerate progress in genomic medicine. Other investigators in the field may be invited to participate in these grantee meetings. Applicants may include travel costs to attend the meeting in-person in their budget. Alternatively, small business grantees may attend virtually.
This notice applies to due dates on or after January 5, 2024 and subsequent receipt dates through September 6, 2026.
Submit applications for this initiative using one of the following notice of funding opportunity (NOFO) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the notice of funding opportunity used for submission must be followed, with the following additions:
Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.
Please direct all inquiries to the contacts in Section VII of the listed notice of funding opportunity with the following additions/substitutions: