National Human Genome Research Institute (NHGRI)
The National Human Genome Research Institute intends to renew the NHGRI Human Genome Reference Program (HGRP) to continue to improve the human pangenome reference resource. During the renewal phase there will be a new emphasis on community outreach, adoption of the resource, and ensuring that it is useful to the full range of investigators working with or relying on human genetic and genomic data.
As one component of the renewal of the HGRP, NHGRI intends to publish the following RFA:
Limited Competition: Human Pangenome Coordinating Center (HPCC) (U41 Clinical Trial Not Allowed)
The purpose of this RFA is to solicit applications to develop and implement the Human Pangenome Coordinating Center (HPCC) for the HGRP. This is a limited competition RFA. Only recipient organizations funded under RFA-HG-19-004 are eligible to apply. The HPCC will create, improve, release, and maintain new pangenome reference versions with an emphasis on activities that will facilitate adoption by the research community.
The Human Pangenome Coordinating Center will implement state of the art and user friendly reference representations for the human pangenome; develop an informatics tool infrastructure and aggregate user-centered pangenome tools; coordinate with other groups to make the resource useful to a broad community of users; accelerate wide use of the pangenome resource by, for example, implementing adopter projects with other genomics consortia; coordinate and expand outreach to international partners; and provide logistical coordination for the HGRP. Applicants will be asked to include a summary of strategies to advance the scientific and technical merit of the proposed project through expanded inclusivity. This is particularly important given the program focus on a resource representative of worldwide populations.
All HGRP awardees will work together in a consortium to produce and improve a human pangenome reference resource that is highly useful to the genomics community and the broader research community that uses a human genome reference. Other components of the HGRP consortium will include:
High Quality Reference Genomes. This component will produce 200 new high-quality human genome assemblies for incorporation into the human pangenome reference. This component will establish criteria and metrics for prioritizing and adding new assemblies to the pangenome, considering scientific goals (such as improving genetic diversity, representation of different populations, and the quantity and quality of new assemblies needed. Samples will also be prioritized to add utility to the resource for basic and clinical studies. This component will include an integrated team of ethical, legal and social implications (ELSI) researchers who will be embedded in the overall HGRP in order to identify and address multiple issues relevant to developing a pangenome resource that is meaningfully representative of human populations.
Informatics Tools for the Pangenome. This multi-award component of the HGRP will develop informatics tools for community use of the human pangenome reference produced by the HGRP. Emphasis will be on tools for common use cases that are relevant to different broad sectors of the genomics community, e.g., clinical, population, and functional genomics
For more information about the HGRP and the human pangenome reference resource, please see https://www.genome.gov/Funded-Programs-Projects/Human-Genome-Reference-Program and https://www.genome.gov/sites/default/files/media/files/2023-02/HGRP-Renewal-Concept.pdf. For a description of the human pangenome resource and existing data see: https://humanpangenome.org/
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The HPCC NOFO is expected to be published in the early Summer of 2023 with an expected application due date in the late Summer of 2023.
Applications are not being solicited at this time.
Please direct all inquiries to:
Alexander Arguello Ph.D.
National Human Genome Research Institute