Notice Number: NOT-HG-20-009
Key DatesRelease Date: November 05, 2019
National Human Genome Research Institute (NHGRI)
The National Human Genome Research Institute, intends to promote a new initiative by publishing two related Requests for Applications to solicit applications for research in the area of Mendelian Genomics Research:
RFA-HG-20-007: Mendelian Genomics Research Centers (U01 - Clinical Trial Optional)
The purpose of this RFA is to establish a consortium aimed at significantly increasing the proportion of Mendelian disorders with an identified genetic cause through enhanced data sharing, collaboration, and an increased focus on the application of new technologies, sequencing strategies, and analytical approaches.
RFA-HG-20-008: Mendelian Genomics Data Coordination Center (U24 - Clinical Trial Not Allowed)
The purpose of this FRA is to solicit applications to develop and implement a Data Coordination Center (DCC) for the Mendelian Genomics Research Consortium. The DCC will receive data and metadata from the MGRCs, ensure the information is complete and appropriately harmonized, and submit it to appropriate resources (e.g., AnVIL, ClinVar, and MatchMaker Exchange).
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in the early winter of 2020 with an expected application due date in the Spring 2020.
. Details of the planned FOA are provided below.
Research Initiative Details
The Mendelian Genomics Research Centers will be expected to:
The Mendelian Genomics Data Coordinating Center will be expected to:
Estimated Total Funding TBD
Expected Number of Awards TBD
Estimated Award Ceiling TBD
Primary CFDA Numbers 93.172
Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
Indian/Native American Tribal Government (Federally Recognized)
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Eligible Agencies of the Federal Government
Please direct all inquiries to:
Lisa Helbling Chadwick, Ph.D.
National Human Genome Research Institute