Notice of Change of Participation of NIH Institutes and Centers in  PAR-11-220, Support of NIGMS Program Project Grants (P01)

Notice Number: NOT-HG-12-013

Key Dates

Release Date: March 19, 2012

Issued by

National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)


The purpose of this Notice is to inform interested investigators that the National Human Genome Research Institute (NHGRI) has been added to the participating components for PAR-11-220, entitled "Support of NIGMS Program Project Grants (P01)," issued by the National Institute of General Medical Sciences (NIGMS).

Part I. Overview Information

Components of Participating Organizations

The Components of Participating Organizations section of PAR-11-220 has been revised to include NHGRI:

National Institute of General Medical Sciences (NIGMS), (
National Human Genome Research Institute (NHGRI), (

Catalog of Federal Domestic Assistance Number


NHGRI Statement of Interest

NHGRI encourages innovative, interactive program project grant applications from institution/organizations that propose to conduct research to significantly advance the development of genomic approaches so that they can be applied effectively to important problems in biology and medicine.  Highest priority will be given to the development of genomic analysis methods that are, or have potential to be applied at high throughput, that produce comprehensive data of the highest quality, and at the same time are cost-effective.  As the choice of which projects to support will be determined in large part by NHGRI-defined programmatic needs, all applicants are strongly encouraged, in the early planning stages of applications, to contact the relevant program officers, who can provide advice about how the proposed project addresses programmatic priorities.  Applicants requesting $500,000 or more in direct costs in any year must contact NIH program staff at least 6 weeks before submitting the application.

Successful program projects generally bring together scientists to apply complementary approaches to work on an important well-defined problem. In genomics these complementary approaches usually involve multidisciplinary teams.  In addition to individual research projects, applicants may propose one or more shared resource cores if needed for the proposed research.  Each shared resource core must provide support and enhance the productivity, cost-effectiveness, and/or research outcome of at least two of the proposed research projects.  New cores may be proposed and/or existing cores may be augmented to support the proposed research. In this way the program project can facilitate the support of essential shared core facilities, e.g., major equipment, although the need of a group of investigators for a major piece of equipment or a core facility does not in itself justify a program project grant.  Administrative cores, except in special, well-justified circumstances, will not be allowed. It is expected that successful program projects will establish effective collaborations, particularly in emerging areas of research that extend beyond the life of the program project grant itself.  Hence, a program project generally has a finite lifetime.

Normally, a program project consists of three to five individual, interdependent projects each with a different PI/PD. All of the projects must be relevant to the common unifying central theme, focus, and overall objective of the entire program project.  Each individual project should reflect a distinct scientific theme relevant to the goals of the program project and be led by an independent investigator. The individual projects must be clearly interrelated and synergistic so that the research ideas, efforts, and outcomes of the program as a whole will offer a distinct advantage over pursuing the individual projects separately.  One PI must be identified as the leader of the program project and that person will be responsible for coordinating the entire program project.  The scientist designated as the program project leader bears responsibility for the overall scientific leadership and fiscal management of the program project grant.  Each of the collaborating scientists responsible for the individual projects will be independent investigators. The option to designate one of the leaders of the individual projects or cores as project leader of the overall application is allowed. In addition, the program project and each individual project must represent a significant effort on the part of the participating scientists and be distinct from their other funded efforts. 

Award Budget:  An upper limit of $3,500,000 direct costs per year may be requested for competing program project grant applications to the NHGRI.  This amount is exclusive of subcontract facilities and administrative costs. Applications that exceed this cost limit without permission from the IC to submit an application will be returned without review. Applications may request up to five years of support.  The amount and duration of award requested is expected to vary with the nature of the research project.

Letter of Intent Due Date:  One month before Application Due Date

Application Due Date:  Standard dates apply

Applications will be evaluated for scientific and technical merit by the Scientific Review Branch, NHGRI, in accordance with NIH peer review policy and procedures, using the stated review criteria.

Applications will be assigned to NHGRI and will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the National Advisory Council for Human Genome Research.

Unless specifically modified in this Notice, all other information provided by PAR-11-220 applies to applications responding to this Notice.

All other aspects of the FOA are unchanged.


Please direct all inquiries to:

Scientific/Research Contact:

Jeffery A. Schloss, Ph.D.
Division of Extramural Research
National Human Genome Research Institute
Telephone:  (301) 496-7531

Peer Review Contact:

Ken Nakamura, Ph.D.
Scientific Review Branch
National Human Genome Research Institute
Telephone:  (301) 402-0838

Financial/Grants Management Contact:

Cheryl Chick
Grants Administration Branch
National Human Genome Research Institute
Phone: (301) 435-7858

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy
NIH . . . Turning Discovery Into Health

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.