Notice of Intent to Publish a Request for Applications to Support Genome-Wide Studies in Biorepositories with Electronic Medical Record Data

Notice Number: NOT-HG-07-009

Key Dates
Release Date:  February 3, 2007

Issued by
National Human Genome Research Institute (NHGRI),

The National Human Genome Research  Institute (NHGRI) plans to issue a Request for Applications (RFA) in the spring of 2007, with review and funding expected by the end of fiscal 2007 (September 2007), to provide support for investigative groups affiliated with existing biorepositories to develop necessary methods and procedures for, and then to perform, genome-wide studies in participants with phenotypes and environmental exposures defined by electronic medical records, with the intent of widespread sharing of the resulting individual genotype-phenotype data. The potential for leveraging existing health care systems for genomic research is vast, particularly in regard to speed, efficiency, cost-effectiveness, and potential for rapid translation to clinical care.  The challenges posed by such research, however, must be carefully examined and addressed if risks are to be minimized and the full value of such repositories realized.  This funding opportunity will define important potential sources of bias and error in phenotypic and exposure data derived from EMR, identify approaches for improving data collection and standardization for genomic research, and examine the feasibility of such enhancements in consultation with EMR experts.  It will also identify sources of concern or confusion among biorepository participants and other relevant groups regarding current consent and consultation processes for application of genome-wide technologies, and for sharing of data; define needs for additional consent and/or consultation; and recommend approaches for improving consent and consultation processes in biorepository-based research.  Applicants will be expected to have access to data and sources of DNA from an existing biorepository with a study population(s) of sufficient size to test the proposed GWA hypotheses within one year of the anticipated date of award.  Funding will be provided to support methodologic development and collaborative activities such as harmonizing phenotypes, developing data capture methods and analytic strategies, assessing data quality and potential biases, and evaluating or improving consent or data protection processes.


For further information regarding this potential RFA, please contact:

Emily L. Harris, PhD, MPH
National Human Genome Research Institute
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305 (U.S. Postal Service Express or regular mail)
Rockville, MD 20852 (express/courier service; non-USPS service)
Telephone: 301-594-6524
FAX: 301-402-2915

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