Amendment to PA-05-014 “Molecular Libraries Screening Instrumentation – SBIR/STTR”

Notice Number: NOT-HG-05-004

Key Dates
Release Date: May 26, 2005

Issued by
National Human Genome Research Institute (NHGRI), (
National Institute of Mental Health (NIMH), (

On November 18, 2004, the National Human Genome Research Institute and the National Institute of Mental Health issued a Program Announcement (PA), entitled “PA-05-014, “ Molecular Libraries Screening Instrumentation – SBIR/STTR ,” that is available at: This Notice is to inform the scientific community that the sponsoring institutes are clarifying the subject areas that are encouraged by this program announcement as follows. These examples are not intended to be comprehensive or limiting.

NHGRI is interested in innovative research on instrumentation for high throughput chemical genomics approaches. The availability of completed genomes has made possible the development of assays and methods to interrogate large swaths of biological space by parallel means, contrasting with classical pharmacological screening assays probing only a single protein or pathway. For example, research proposals for development of novel instrumentation incorporating massively parallel protein array methods or for research on high content cellular imaging devices could be consistent with the objectives of the NHGRI.

NIMH is interested in high throughput molecular instrumentation technologies with utility for neuroscience -related research. While we recognize the final product developed could be applied to a number of different organ systems or disorders, we are interested in ones with an initial emphasis on neuroscience. Examples might include high throughput electrophysiological systems to measure neuronal function, imaging systems to measure synaptic function, systems that focus on brain receptor function, etc.

Researchers considering proposals for high throughput screening instrumentation technologies that might be appropriate for other NIH institutes or centers should contact the program officer in the relevant institute. . For institute and center program contacts, please visit this website:


Bradley A. Ozenberger, Ph.D.
Division of Extramural Research
National Human Genome Research Institute
National Institutes of Health, DHHS
Suite 4076 - MSC 9305
5635 Fishers Lane
Bethesda, MD 20892-9305
(express/courier services should be directed to Rockville, MD 20852)
Telephone: (301) 496-7531

Margaret C. Grabb, Ph.D.
Chief: SBIR and STTR Programs
Translational Research and Scientific Technology Office
Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
6001 Executive Blvd., Rm 7201 MSC 9645
Bethesda, MD 20892-9645
(express/courier services should be directed to Rockville, MD 20852)
Tel: (301) 443-3563

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