DEVELOPMENT OF A PUBLICLY AVAILABLE RESOURCE TO FACILITATE THE INTERNATIONAL HAPLOTYPE MAP (HapMap) PROJECT AND OTHER STUDIES ON GENETIC VARIATION RELEASE DATE: June 5, 2003 NOTICE: NOT-HG-03-003 National Human Genome Research Institute (NHGRI) The NHGRI has, over a period from approximately January 2002 to June 2003, invited several P41 resource development applications for the collection of blood samples for the International Haplotype Map Project ("HapMap") and related research on haplotype variation. The purpose of the HapMapProject and of the related research is to generate data about haplotype variation in populations whose ancestors come from various parts of the world. The initial determination of the populations to be included in this research was made based on the recommendation of an initial planning group for the project convened by NHGRI. Because of the need to collect these samples in a timely manner and the requirement for meaningful engagement or consultation of the communities to be approached for participation, the initial planning group and the NHGRI Advisory Council agreed that prospective applicants should be able to demonstrate pre-existing relationships with the relevant communities, and the initial planning group suggested to NHGRI staff potential reserachers who had this capability. The applicants for these proposals were identified in this way and were invited to submit applications. The applications are designated as P41 resource development applications because samples that are collected will be available as a public resource through the Coriell Institute for related future research on genetic variation. An integral part of the proposals is also the deveopment of methodologies for consulting with the relevant communities about the HapMap Project and related research on haplotype variation, and for generating data about the attitudes and concerns of the communities about genetic variation research. All applications submitted in response to this request are subject to the standard NIH peer review system--review by a study section convened by the NHGRI's Scientific Review Branch and consideration by the National Advisory Council on Human Genome Research. Some of the applications have already been reviewed and funded. Two applications are currently under consideration. For information about the HapMap Project, please visit our website: http://www.genome.gov/10001688. Program Contact: Jean E. McEwen, J.D., Ph.D. Program Director Ethical, Legal, and Social Implications Program National Human Genome Research Institute National Institutes of Health jm522n@nih.gov http://www.genome.gov/10001618
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