Notice of Intent to Publish a Funding Opportunity Announcement for Intellectual and Developmental Disabilities Research Centers 2025 (P50 Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
June 10, 2024
Estimated Publication Date of Notice of Funding Opportunity :
July 26, 2024
First Estimated Application Due Date:
November 26, 2024
Earliest Estimated Award Date:
July 01, 2025
Earliest Estimated Start Date:
July 01, 2025
Related Announcements
  • November 15, 2019 - Intellectual and Developmental Disabilities Research Centers 2020 (P50 Clinical Trial Optional). See NOFO RFA-HD-20-016.
Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to reissue a Notice of Funding Opportunity (NOFO) to solicit applications for research to advance the diagnosis, prevention, treatment, and amelioration of intellectual and developmental disabilities (IDD) through Intellectual and Developmental Disabilities Research Centers (IDDRCs). Each IDDRC will promote highly collaborative, basic, translational, and clinical research in IDD.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Summer 2024, with an expected application due date in Fall 2024. 

This NOFO will utilize the P50 activity code, which supports specialized centers through multi-project grant awards to support research activities. Pertinent details of the planned NOFO are provided below.

Research Initiative Details

The Intellectual and Developmental Disabilities Research Centers (IDDRCs) comprise a cooperative network composed of multiple P50 Centers that facilitate basic, clinical, and applied research in IDD. This Notice encourages investigators with expertise and insights into this area of IDD to begin to consider applying for this NOFO.

In addition, collaborative investigations combining expertise in translational science, biomarker assessment, outcome measure development, tool validation, bioinformatics, and therapeutic development will be encouraged, and these investigators should also begin considering applying for this application.

Each IDDRC application for the FY2025 competition is expected to include the following components:

  • Administrative Core
  • Clinical Translational Core
  • 1-2 Additional Core(s)
  • 2-3 Specific Research projects designed to improve the translation of existing knowledge or strategies for the prevention, treatment, and/or amelioration of IDD
  • Outside research projects funded by federal, state, and private sources
  • Plans for outreach, engagement and dissemination to the community
  • Plan for Enhancing Diverse Perspectives (PEDP)

Proposals are expected to include plans for outreach and dissemination along with a specific strategy for community engagement as part of the Administrative Core. Proposals will be expected to establish meaningful partnerships with the community, including persons with lived experience (PWLE) of disabilities. The IDDRC should incorporate the experiences, perspectives, needs, and priorities of stakeholders, including those with IDD, into its decisions and activities.

Each IDDRC must propose at least two specific research projects, but no more than three. When the NOFO is published, areas of research interest will be indicated.

Funding Information

Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling

$1.0 M in direct costs per year (maximum 5-year duration of award).

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Melissa A. Parisi, M.D., Ph.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-435-6880