Notice of Intent to Publish a Notice of Funding Opportunity for the PATC H-IN Implementation Science Coordinating Center (UM2 Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
April 12, 2023
Estimated Publication Date of Notice of Funding Opportunity :
July 28, 2023
First Estimated Application Due Date:
December 06, 2023
Earliest Estimated Award Date:
July 01, 2024
Earliest Estimated Start Date:
July 01, 2024
Related Announcements


Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other NIH Institutes and Centers (ICs) including the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the Fogarty International Center (FIC), intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to participate in a research program cooperative agreement to support the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN).  The Network will expand and/or improve successes achieved by PATC3H to new geographic settings with limited implementation science (IS) research capacity and/or risk populations who are poorly represented in international adolescent HIV research (e.g. sexual and gender minorities; commercial sex workers; drug users) and stimulate much needed IS research in a neglected area of public health significance: prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). These settings must have an HIV epidemic density defined by UNAIDS estimates as either a country 1) in which at least 200,000 people are living with HIV and the number has not decreased by more than 5% over the last 2 consecutive years of available data or 2) has an HIV incidence among youth ages 10 to 24 years of 0.01% or more.

The structure of PATC3H-IN shall consist of three highly integrated components: (1) 4-5 UG1 Clinical Research Centers (CRC), applications for which have previously been solicited (RFA-HD-23-013); (2) a Coordination and Operations Center (COC); and (3) an Implementation Science Coordinating Center (ISCC).

This Notice serves to announce a forthcoming NOFO that solicits applications for a single Implementation Science Coordinating Center.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. To apply, investigators will be expected to demonstrate capacity to form successful collaborations, both within the PATC3H-IN network and among its investigators as well as with external stakeholders, to advance achievement of the research objectives and maximize sustainability of efficacious interventions and best practices.

The NOFO is expected to be published in Summer 2023 with an expected application due date in Winter 2023.

This NOFO will utilize the UM2 (Clinical Trial Optional) activity code. Details of the planned NOFO are provided below.

Research Initiative Details

PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific HIV prevention and/or HIV care continuum and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices.

The PATC3H-IN Implementation Science Coordinating Center (ISCC) is expected to provide advanced statistical modeling, stakeholder engagement and research education, coordination, and infrastructure support for several core operations of PATC3H-IN, including support for capacity building infrastructure and the conduct of hypothesis-driven implementation research to support effective translation of network outputs. Activities will include conducting research on dynamic changes in HIV policy and practice in regional health ministries or other local health authorities and relevant community-based HIV-related service settings; conducting novel studies applying cutting edge analytical techniques to existing data and data collected across PATC3H-IN; providing resources for advanced methodological and analytical techniques across the network; disseminating research from the cooperative to a wide variety of external stakeholders; and facilitating bidirectional communication between external stakeholders and network investigators. The ISCC will also optionally conduct novel empirical research that may ensure timely understanding of changes in current practices across regions where PATC3H-IN CRCs are working to address the youth-specific gaps in the HIV prevention and/or HIV care continuum (PHCC) to improve health outcomes for at-risk adolescents and youth living with HIV.

The ISCC will provide a series of core resources to the network, and investigators are encouraged to convene a diverse, multidisciplinary, skilled team that provides synergy with PATC3H-IN by working together with other components and investigators in the network.

A pre-application webinar is planned for summer 2023.

Funding Information


Estimated Total Funding


Expected Number of Awards


Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Franklin W. Yates, MD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 240-890-3679