Notice of Special Interest (NOSI): Climate Change and Health Administrative Supplements
Notice Number:
NOT-HD-23-006

Key Dates

Release Date:

March 9, 2023

First Available Due Date:
May 08, 2023
Expiration Date:
May 09, 2023

Related Announcements

PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Aging (NIA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of Mental Health (NIMH)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

Fogarty International Center (FIC)

National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Office of Behavioral and Social Sciences Research (OBSSR)

Office of Research on Women's Health (ORWH)

Purpose

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), in partnership with the National Institute of Environmental Health Science (NIEHS), Fogarty International Center (FIC), National Institute of Minority Health and Health Disparities (NIMHD), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR), National Heart Blood and Lung Institute (NHBLI), and National Institute of Allergy and Infectious Disease (NIAID) is involved with an NIH-wide Climate Change and Health Initiative (CCHI) with the goals of: reducing the health threats posed by climate change across the lifespan; improving the health equity of people who are at increased risk from or disparately affected by climate change impacts; and building health resilience among individuals, communities, and nations around the world. As a part of this CCHI, the participating Institutes and Centers (ICs) invite applications to supplement active NIH awards to seed new activities and partnerships in climate change and health (CCH) research and research training. We particularly invite applications for supplements to grants that are not currently focused on CCH but wish to include CCH measures and outcomes within the scope of their current research and training specific aims, for example by extending CCH metrics to existing cohorts and studies or by supporting additional CCH areas within broadly defined Center or Hub grants. We will also accept supplement applications to grants already focused on CCH, for example to expand their activities to new populations, modeling activities, exposure measurements, and health outcomes. As administrative supplements, the activities proposed must be within the scope of the parent grant specific aims. Applicants are encouraged to bring in new partners, as needed, who will provide climate science and related expertise and begin to build multidisciplinary teams for future research in this area.

The over-arching intent of this solicitation is to: (1) enrich and expand the research community in CCH to include new researchers from multiple disciplines, both in the US and in low- and middle-income countries (LMICs) globally; and (2) conduct research that will create new knowledge to reduce or mitigate health threats attributable to climate change across the lifespan and build health resilience or develop adaptation mechanisms for individuals, communities, and nations around the world, especially among those at increased risk from, or disproportionately affected by, the impacts of climate change. Awardees are expected to seek competing support to continue promising leads from the research supported through the supplement. This supplement opportunity is part of a larger NIH CCH initiative that seeks to build a global community of practice that will work towards trans-disciplinary solutions-driven science to address the serious impacts of climate change on health.

Investigators who are uncertain whether the proposed project qualifies as CCH as defined by NIH, or whether the proposed activities fall within the scope of the parent grant, are encouraged to contact the relevant Point of Contact from the IC supporting the parent award, listed below.

Background, Definitions, and Areas of Interest

For some time, international scientific consensus has been that climate change poses an existential threat to human beings. The Intergovernmental Panel on Climate Change (IPCC), the United Nation’s body for assessing the science related to climate change, concluded in a recent report: Any increase in global warming is projected to affect human health, with primarily negative consequences (high confidence) , (IPCC 2018a: https://www.ipcc.ch/sr15/chapter/spm/). The report further concludes that, Compared to current conditions, 1.5 C of global warming would nonetheless pose heightened risks to eradicating poverty, reducing inequalities and ensuring human and ecosystem well-being (medium evidence, high agreement) , (IPPC 2018b: https://www.ipcc.ch/sr15/chapter/chapter-5/).

The complexity of climate change impacts on health are enormous. Climate drivers affect health outcomes directly through weather events such as extreme heat, wildfires, droughts, storm surges, and floods, but also indirectly through a series of exposure pathways such as air and water quality, food quality, infectious diseases, and massive population displacement events. These pathways are themselves influenced by environmental contexts related to land use, geography, infrastructure, and agriculture, as well as social, behavioral, and economic contexts that create vulnerabilities associated with life stage, gender, poverty, discrimination, and access to care.

Climate change greatly elevates threats to human health across a wide range of illnesses and injuries, including asthma, respiratory allergies and airway diseases, cancers, cardiovascular disease and stroke, foodborne diseases and decreased nutrition, heat-related illness and deaths, reproductive, birth outcome, and developmental effects, mental health and neurological disorders, vector-borne and zoonotic diseases, waterborne diseases, and extreme weather-related morbidity and mortality. All scientific areas supported by NIH are relevant to CCH. Administrative supplements are therefore invited across a spectrum of research, fellowship, and training grants (see allowable mechanisms, below), and research in all domains (from basic to applied areas of interest) are welcome. The NIH initiative in CCH identifies four core pillars and diverse areas of science (see below). Responsive projects may be in any of these areas. Projects are encouraged to employ trans-disciplinary approaches and the engagement of communities, policy makers, the private sector, and other stakeholders, as appropriate. Investigators are expected to assemble appropriate teams to carry out the research and training proposed, including reaching out to new partners not participating in the parent grant. For more details on the core pillars and areas of science, see the NIH CCH Initiative Strategic Framework (https://www.nih.gov/climateandhealth).

Core Pillars of CCH Initiative:

Health Effects Research: Scientific investigation of the influences of climate change on health outcomes, including spatial and temporal scales, pathways, and mechanisms, and risks at specific times of vulnerability across the lifespan, as well as to special populations including children, older adults, women, pregnant women, differently abled persons, and others.

Health Equity: Emphasis and integration throughout the Initiative on recognizing and responding to the needs of populations most at risk of climate change impacts to their health.

Intervention Research: Science that provides the evidence base for development and implementation of timely, effective strategies to prevent disease and disability and promote health. Intervention research uses experimental, modeling, and evaluative methods to study and design interventions to improve health, including individual interventions, community-level interventions, policy interventions, engineered solutions, institutional and infrastructure changes, and clinical, social, behavioral, and communication tools that influence beneficial decision making.

Training and Capacity Building: Transmission of the fundamental knowledge and skills to conduct multidisciplinary climate and health science, develop innovative supporting technologies, and translate findings to facilitate understanding of and adaptation to the growing threat of climate change on health.

Within the four Core Pillars of the CCH initiative, priority areas of science include:

  • Adaptation research
  • Basic and mechanistic research
  • Behavioral and social science research
  • Data integration
  • Disaster research response
  • Dissemination and implementation science
  • Epidemiology and predictive modeling
  • Exposure and risk assessment
  • Systems science
  • Trans-disciplinary Partnerships

The NIH Climate Change and Health Strategic Framework identifies the crucial need for partnerships that expand and deepen the available intellectual, technological, data resources and population-based participation necessary to conduct impactful research in this area.

Examples of responsive projects include, but are not limited to, the following:

  • Addition of climate, geospatial, and meteorological data to existing populations studies to analyze impacts of climate trends.
  • Conduct exposure characterization for climate factors in community study of heat impacts at a local level.
  • Enhancing multi-scale data on health systems to assess climate resilience of a community.
  • Introducing biomarkers of climate-induced stress in studies of high-risk pregnancies.
  • Understanding the social determinants of health and access to mental health services in global communities who are at high risk of extreme weather events.
  • Determining the feasibility of early preparedness interventions in regions experiencing wildfires.

Aspects of more comprehensive studies, such as the following, might also be addressed in a supplement:

  • Identifying the most effective ways to protect inner-city, pregnant women and elderly from the impacts of extreme temperatures, especially heat
  • Determining how best to test and adapt protocols for delivery of mental health services to communities during hurricanes, wildfires, and other extreme weather events
  • Assessing what kinds of behavior change strategies might provide health co-benefits during climate mitigation
  • Learning how population-based studies and implementation research might influence uptake and scale-up of clean fuels in global energy replacement programs
  • Applying modeling originally developed to assess health effects of air pollution to climate-sensitive diseases such as asthma, as it relates to climate change impact
  • Elucidating the effects of climate change across the cancer control continuum, including exposure to air pollution, ambient temperature effects on UV radiation and physical activity patterns, and access to cancer care
  • Modeling the likely effects of climate adaptations in infrastructure on water-borne and vector-borne disease incidence
  • Quantifying co-benefits to cardiovascular health of reducing reliance on fossil fuels
  • Identifying aspects of food production and distribution that can reduce risk of contamination, maintain nutrient levels, and ensure sustainable access
  • Understanding the effects of climate change-induced stress on reproduction and development
  • Understanding the effects of climate change-induced stress on food systems, food security, and nutrition security
  • Understanding how climate change might alter social and economic determinants of mental health and community well-being
  • Evaluating the impact of federal, state, or local climate policies on health outcomes (particularly among people experiencing health inequities, such as NIH-designated health disparity populations)
  • Pilot intervention studies involving individual, community or multilevel strategies to reduce, adapt to, mitigate, or increase resilience to adverse health effects directly or indirectly caused by climate change especially in vulnerable populations.
  • Initiating or expanding community engaged research focused on CCH topics. This type of research involves a process of working collaboratively with and through groups of people affiliated by geographic proximity, special interest, or similar situations to conduct research that addresses CCH topics. It may involve partnerships and coalitions and may include organized groups, agencies, institutions, or individuals.

The following topic areas are NOT within scope for this NOSI:

  • The impact of climate change on the environment, natural resources, or the economy without a clear link to public health or health-related outcomes.

Additional specific areas of interest

In addition to overarching areas of interest, individual NIH Institutes, Centers, and Offices have indicated the following specific areas of research interest:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

The NICHD mission is to lead research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. The NICHD's broad and diverse research portfolio includes research related to conception and pregnancy; typical and atypical development in childhood; childhood trauma, injury, and critical illness; the transition from adolescence to adulthood; reproductive health; rehabilitation; intellectual, developmental, and physical disabilities; and population dynamics across the lifespan.

NICHD will accept supplement requests for studies related to climate change from currently active awardees.

Topics of interest to NICHD include, but are not limited to, research on:

  • Measurement and surveillance of the impact of climate change on health and NICHD priority populations, including pregnant women, children, and people with disabilities
  • Effects of climate change on population dynamics including fertility, mortality and morbidity, and population movement, distribution, and composition
  • Data collection on how climate change affects the health, development, and productivity of NICHD priority populations using population-based demographic or economic approaches and scientifically valid probability samples
  • Impact of climate change on reproductive health; infertility; and maternal, prenatal, pregnancy, and child health; child development; and disability.
  • Interactions between climate change and land use and their effects on population dynamics and the health of NICHD priority populations
  • The nexus of climate, food systems and health including the impact of climate change on sustainable and resilient food systems and the ability to meet public health goals, including dietary guidance, especially infant feeding practices.
  • The intersection of climate and vector-born disease (susceptibility to and treatment of) and their impacts on outcomes such as migration and nutrition status among NICHD priority populations
  • The impact of climate on pre-existing food insecurity and resulting intervention choices to address child or family malnutrition (over-/under nutrition) particularly in low-resource settings in the United States and globally, as well as reciprocity between food insecurity and climate
  • Research on populations affected by infectious diseases (e.g., HIV/AIDS) likely to change in incidence or prevalence due to climate change, including epidemiological studies to evaluate the likely effects of climate change on the burden of these diseases.

National Cancer Institute (NCI)

The National Cancer Institute (NCI) coordinates the National Cancer Program, which conducts and supports research and training efforts to improve cancer prevention, reduce the risk, incidence, and deaths from cancer, and enhance the quality of life of cancer survivors. The NCI is interested in supporting research relevant to advancing the understanding of the effects of climate change on cancer risks, control, and survivorship, and ways to prevent or mitigate negative health effects. The NCI encourages supplement requests with consideration for populations that experience cancer health disparities and are likely to experience a disproportionate burden of effects from a changing climate. Priority areas include, but are not limited to supplement requests that:

  • Investigate physical, chemical, and biological exposures related to climate change and cancer etiology and outcomes.
  • Investigate the co-benefits of behaviors linked to cancer control and climate change adaptation or mitigation such as adoption of plant-based diets and increased physical activity through use of active transportation.
  • Understand the effects of climate change on healthcare delivery and outcomes among patients undergoing cancer treatment, and cancer survivors.
  • Understand factors that influence and support adaptive capacity of community and healthcare delivery settings.
  • Examine health equity and social determinants of health related to climate change and climate change mitigation and adaptation.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Climate change can have far-reaching effects on human health, including on diseases such as diabetes, endocrine and metabolic diseases, digestive diseases, nutritional disorders, obesity, kidney, urologic, and hematologic diseases. The impact of climate change can manifest in several ways, such as heat waves and extreme temperatures exacerbating conditions like diabetes and cardiovascular disease. Additionally, climate change can affect the quality and availability of food, which can lead to nutritional deficiencies and an increased risk of metabolic diseases and obesity. The rise in temperatures and changes in precipitation patterns can also contribute to an increase in the prevalence of type-2 diabetes. Furthermore, changes in food production and distribution caused by climate change can impact the incidence of digestive diseases and nutritional disorders. Climate change can impact the prevalence of kidney, urologic, and hematologic diseases due to changes in water availability and quality.

NIDDK's mission is to support medical research, research training, and dissemination of science-based information on diabetes, endocrine and metabolic diseases, digestive diseases, nutritional disorders, obesity, kidney, urologic, and hematologic diseases to improve people's health and quality of life. NIDDK is particularly focused on those populations who are at an elevated risk or disparately affected by the impacts of climate change in their research areas. By broadening research efforts, NIDDK aims to accelerate the elimination of health disparities and promote health equity for all, acknowledging that climate change can have far-reaching effects on human health, including exacerbating these diseases.

Climate and health topics of particular interest to NIDDK include (but are not limited to):

  • Understanding the impacts of climate change on the prevalence and incidence of diabetes, endocrine and metabolic diseases, digestive diseases, nutritional disorders, obesity, kidney, urologic, and hematologic diseases.
  • Leveraging data science, artificial intelligence (AI), and modeling techniques to gain insight into the effects of climate change in these disease areas.
  • Developing interventions to mitigate the impacts of climate change on health outcomes in these disease areas.
  • Investigating the mechanisms underlying the relationship between climate change and health outcomes in these disease areas.
  • Developing strategies to promote health equity and reduce health disparities in vulnerable populations affected by climate change impacts in these disease areas.

For more information, please see: https://www.niddk.nih.gov/about-niddk/research-areas.

National Heart, Lung, and Blood Institute (NHLBI)

The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.

NHLBI will accept supplement requests for studies related to climate change from currently active R01, R33, and UG3 awardees. Other grant mechanisms are not eligible for a NHLBI climate change administrative supplement.

Topics of interest to NHLBI include, but are not limited to, research on:

  • Effects of climate change (such as heat waves or air pollution) on the prevention or treatment of heart, lung, blood, and sleep disorders such as sickle cell illness, iron deficiency anemia, other anemias, asthma, chronic obstructive pulmonary diseases, other chronic pulmonary diseases, premature atherosclerosis, heart failure, myocardial infarctions, arrhythmias, hypertension, coagulopathies, and venous thromboembolism
  • Impact of climate change on development of cardiovascular, lung, blood, and sleep disorders (HLBS) in pregnant people and offspring
  • The impact of climate change on risk factors for HLBS over the lifespan including impact on obesity prevention or treatment, and behaviors such as diet, physical activity, and sleep, and social determinants of health
  • The merger or integration and analysis of datasets related to climate change with health datasets of risk factors or disease occurrence for HLBS. Health datasets may include omics datasets, and analyses may include use of contemporary methods such as machine learning or artificial intelligence
  • Pilot studies investigate the variation in mitigation and adaption at the state, regional or local practices and policies (such as public messages or changes in school ventilation systems) and their relationship between the occurrence of HLBS risk factors or outcomes.
  • Study the HLBS health effects of changes to agricultural practices as they relate to mitigation or adaptation to climate change
  • Links between geographic context, environmental determinants, and impact on HLBS
  • Effects of climate change on genetic adaptability, genomic response, and omics of HLBS disorders or risk factors
  • Impact of psychosocial stress from climate-related disasters on HLBS disorders
  • The feasibility, adoption, and/or health effects of dietary practices with lower impact on climate change, such as plant-based rather than animal-based diets

National Institute on Aging (NIA)

The National Institute on Aging (NIA) is accepting applications that study the effect of Climate Change (including extreme climate events, etc.) on mechanisms of aging, the health of older adults (including caregivers) or on the incidence, disease progression, and/or care of people with dementia within the NIA mission (see NIA).

Topics of interest to NIA include, but are not limited to, research on:

  • Short- and long-term health impacts of extreme weather and climate change on the health and wellbeing of older adults and their caregivers in the U.S. and internationally.
  • Climate-related vulnerabilities associated with inequities in mid- and later-life health and wellbeing.
  • Protection, adaptation, and mitigation factors that can reduce the impacts of climate exposure on older adult health and wellbeing, as well as that of their caregivers.
  • Impacts of extreme weather and climate change on biological mechanisms of aging.

Applicants are strongly encouraged to contact NIA Scientific/Research staff prior to their submission to discuss the responsiveness of their supplement application. Supplements that build on existing programs, research with laboratory, domestic, captive or wild animals, and cohorts involving at-risk groups in the U.S., underserved populations, and in low- and middle-income countries are encouraged. Utilization of the NIA Health Disparities Research Framework is encouraged.

National Institute of Allergy and Infectious Diseases (NIAID)

  • Elucidating the effects of climate change-associated variations on the exposure of populations to allergens and on physiologic and pathologic responses to such allergens
  • Elucidating the effects of climate change-associated variations (e.g., in environmental and ecologic conditions) on the reproductive capacity, virulence, transmissibility and epidemiology of microbial pathogens
  • Supporting epidemiological studies to evaluate the likely effects of climate change on the burden of zoonotic, food-, water-, and vector-borne diseases
  • Modeling the likely effects of climate adaptations in infrastructure on zoonotic, food-, water-, and vector-borne disease incidence and prevalence
  • Elucidating the effects of climate change on the population biology of vectors responsible for transmission of microbial pathogens
  • Assessing the impact of climate change on vector competence, e.g., the impact of changes in temperature on pathogen replication and/or transmissibility, and on human-vector contact
  • Increasing understanding of the impacts of rising humidity and temperature on enteric pathogens, such as diarrhea-associated adenoviruses, rotavirus, caliciviruses, Campylobacter jejuni, Listeria monocytogenes, diarrheagenic Escherichia coli, Salmonella spp., Shigella spp., and Vibrio spp.
  • Increasing understanding of the impacts of climate change-associated changing or increasing water temperatures on enteric pathogens, such as diarrhea-associated adenoviruses, rotavirus, caliciviruses, Vibrio spp., Salmonella, or other pertinent enteric pathogens
  • Assessing the interactions among climate drivers [such as ecosystem changes (e.g., flooding, severe weather, drought) and water quality] and enteric pathogens, e.g.,
    • Flooding associated with dispersion of enteric bacterial pathogens
    • Drought associated with concentration of enteric bacterial pathogens
  • Increasing understanding of the impacts of climate change on drinking water infrastructure and enhanced risks of waterborne diseases, e.g.,
    • Clean water shortages and changes in agriculture practices, e.g., use of sewage contaminated water for irrigation and flooding of sewage systems caused by excessive rainfall, that alter the epidemiology of zoonoses and enteropathogenic disease

National Institute of Environmental Health Sciences (NIEHS)

The mission of the National Institute of Environmental Health Sciences (NIEHS) is to discover how the environment affects people to promote healthier lives. The NIEHS is interested in supporting research that addresses the impact of climate change on environmental health and innovative approaches to the development of prevention and intervention strategies to reduce the impacts of climate change on environmental health, particularly in communities most susceptible to these impacts Examples of environmental exposures relevant to the mission of the NIEHS include, but are not limited to, industrial chemicals or manufacturing byproducts, e-waste, metals, pesticides, herbicides, and inhaled toxicants, extreme weather, and the environmental impacts of natural and man-made disasters. NIEHS supports research on climate change and health that examines the interplay between environmental exposures and individual and structural-level (e.g., structural racism) social determinants of health.

Climate and health topics of particular interest to NIEHS include (but are not limited to):

  • Cumulative health risks of multiple chemical and non-chemical stressors across the lifespan (i.e., accumulating burden of climate-driven exposures during critical windows of susceptibility)
  • Mechanistic research using in vitro, in vivo, and new fundamental research methods particularly for understudied exposures (e.g., criteria air pollutants and air toxics other than ozone and particulate matter)
  • Community-engaged, solutions-focused climate justice research in communities experiencing a disproportionate burden of impact (i.e., prevention, adaptation, intervention, and implementation approaches to minimize the health impacts of climate change)
  • Natural disaster research (e.g., air pollution from wildfires, toxic chemicals in flood waters, changes in fungicide, pesticide or fertilizer use due to associated drought conditions or flooding events, or exposure to harmful conditions during post-disaster clean up).
  • Exposures of emerging concern (e.g., changes in the toxicity of micro/nanoplastics or harmful algal blooms in fresh and salt water in response to climate change conditions)
  • Intersection of the built, physical/chemical, and social environments (e.g., frequent flooding promotes mold in buildings, increases exposure to toxic chemicals in floodwaters and high poverty areas with fewer resources for safe clean up and improved flood water management).

National Institute on Minority Health and Health Disparities (NIMHD)

The mission of the NIMHD is to lead scientific research to improve minority health and reduce health disparities. NIMHD focuses on all aspects of health and health care for racial and ethnic minority populations in the U.S. and the full continuum of health disparity causes as well as the interrelation of these causes. NIMHD projects must include a focus on one or more of the following populations that NIH-designates as experiencing health disparities in the United States and its territories: African Americans, Latinos/Hispanics, American Indians and Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, less privileged socioeconomic groups, underserved rural populations, and sexual and gender minorities. Comparison groups/populations may also be included as appropriate for the research questions posed. NIMHD encourages projects that use approaches encompassing multiple domains of influence (e.g., biological, behavioral, sociocultural, environmental, physical environment, health system) and multiple levels of influence (e.g., individual, interpersonal, family, peer group, community, societal) to understand and address health disparities (see the NIMHD Research Framework, https://www.nimhd.nih.gov/about/overview/research-framework.html, for more information). Studies using animal models or studies based outside the U.S. or its territories will not be supported by NIMHD under this NOSI.

NIMHD will accept supplement requests for studies related to climate change from the currently active awardees of the following grant mechanisms: R01, R15, U24, U54, and P50.

National Institute of Nursing Research (NINR)

The National Institute of Nursing Research (NINR) supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses practice, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest.

Office of Disease Prevention (ODP)

The ODP is the lead office at the NIH responsible for assessing, facilitating, and stimulating research in disease prevention. In partnership with the 27 NIH Institutes and Centers, the ODP strives to increase the scope, quality, dissemination, and impact of NIH-supported prevention research. The ODP co-funds research that has strong implications for disease and injury prevention and health equity and that includes innovative and appropriate research design, measurement, and analysis methods. The ODP has a specific interest in projects that develop and/or test preventive interventions.

The ODP provides co-funding for, but does not award grants. Applications must be relevant to the objectives of a funding NIH Institute or Center (IC) listed in this announcement. Please reach out to the IC contacts listed for questions regarding research priorities and funding. ODP only accepts co-funding requests from NIH ICs. For additional information about ODP, please refer to the ODP Strategic Plan for Fiscal Years 2019 2023.

The Office of Research on Women’s Health (ORWH)

The Office of Research on Women’s Health (ORWH) is part of the Office of the Director, NIH, and works with the 27 NIH Institutes and Centers to advance rigorous research addressing women’s health issues. ORWH invites applications to supplement active NIH awards from any of the NIH Institutes and Centers (ICs) listed in the announcement to conduct research on the impact of climate change on women’s health and health disparities across the lifespan in the US and in Low- and Middle-Income countries (LMICs). Applications seeking ORWH co-funding, in response to this FOA, should ensure that the proposed work is aligned with at least one goal and objective outlined in the Trans-NIH Strategic Plan for Women’s Health Research (https://www.nih.gov/women/strategicplan).

ORWH encourages interdisciplinary approaches to leverage knowledge and expertise in the research questions being explored. For this announcement, ORWH is interested in applications that support:

  • Research on the impact of climate change on women’s cardiovascular and respiratory diseases across the lifespan with a special interest in the perinatal period.
  • Research on the impact of extreme temperatures on women’s health, and on adaptive and innovative approaches that mitigate health effects of extreme temperatures.
  • Research on the impact of air pollution and heat exposure on pregnancy outcomes in populations of women from undeserved communities including stillbirth, preterm birth, and low birth weight in the US and LMICs.
  • Training of scientists and health professionals to conduct research on women’s climate health issues.

Eligibility and Eligible Activity Codes:

Active awards with project end dates in FY2024 or later (exclusive of no cost extensions) are eligible. However, some ICs will not fund supplements in the final year of a grant. To confirm eligibility, applicants are encouraged to contact staff at the Institute supporting the award when planning the request.

Additional funds may be awarded as supplements to parent awards using any Activity Code that is listed in PA-20-272 with the following exceptions.

Small business activity codes (such as R41, R42, R43, R44, U44, and Fast Track) are excluded as well as G20, PS1, P60, U42, and UG1 awards. T awards are also excluded.

Centers and multi-project grant mechanisms are eligible. Grants already focused on CCH must describe how the proposed activities will enrich and expand the specific aims of the parent grant and provide a strong justification for why existing funds. Grants conducting research or research training in the U.S. or LMICs are eligible. LMICs are defined by the World Bank (https://datahelpdesk.worldbank.org/knowledgebase/articles/906519 ) and include all classifications except high income countries .

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

  • Application Due Date May 8, 2023, by 5:00 PM local time of applicant organization.
  • For funding consideration, applicants must include NOT-HD-23-006 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Only electronic submissions will be accepted for this funding opportunity. Use one of the methods described in PA-20-272. Paper submissions and applications submitted as attachments will be returned.
  • Requests may be for one year of support only and the project and budget periods must be within the currently approved project period for the existing parent award.
  • Individual requests can be no more than $375,000 in direct costs. In addition, requested direct costs cannot exceed the direct costs for the parent grant in the FY23 budget.
  • Applicants may not apply for more than one supplement to a given parent grant.
  • The Research Strategy section of the application is limited to 6 pages.
  • As part of the application, investigators must submit an abstract of the proposed supplement research or research training that shows the relevance to Climate Change and Health. Place the abstract in the Project Summary/Abstract section of the SF424 (R&R) form.
  • Applicants are strongly encouraged to notify the program contact at the Institute supporting the parent award that a request has been submitted in response to this NOFO in order to facilitate efficient processing of the request.

Applications submitted in response to this NOSI are strongly encouraged to include the following information:

  • An abstract outlining the relevance of the supplement to climate change and health.
  • At the beginning of the Research or Training Plan, a brief description of the specific aims of the parent award and an explanation of how the new CCH activities relate to these specific aims.
  • A brief description of the relevant expertise for the proposed new activities, including key investigator biosketches.
  • A description of the research or research training proposed, including proposed methods and expected outcomes.
  • An indication of which of the core pillars and diverse scientific areas (outlined above) the research will address.
  • A statement about the potential impact of the proposed supplement or future follow-on work to advance the understanding, tools, metrics, or practices for mitigating or preventing health impacts of climate change.
  • A proposed timeline of activities and milestones for the 12-month supplementary funding period.

Review Process

Administrative supplement requests will undergo administrative and scientific evaluation by NIH Program staff from the participating Institutes and Centers. Recommendations will be made to the CCH Executive Committee for funding consideration.

Criteria (check parent Administrative Supplement FOA for additional review impact criteria)

  • Does the work proposed focus on climate change and health and fall within the four pillars of the CCH initiative and priority areas of science outlined above?
  • Is the proposed work within scope of the parent grant?
  • Are the proposed methods and techniques rigorous and appropriate?
  • Is the proposed team appropriate and qualified to carry out the proposed project?
  • Are the proposed milestones and timeline feasible and can they be completed within the period of the supplement?
  • Is the proposed work likely to lead to new applications or research that will advance the goals of the CCH initiative?

Inquiries

Scientific/Research Contacts
Andrew Bremer, PhD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-402-7886
Email: andrew.bremer@nih.gov

Larry Fine, PhD
National Heart, Lung, and Blood Institute (NHLBI)
Phone: 301-435-0305
E-mail: lf128x@nih.gov

Nina Silverberg, Ph.D.
National Institute on Aging (NIA)
Division of Neuroscience (DN)
Phone: 301-496-9350
E-mail: silverbergn@mail.nih.gov

Adriana Costero-Saint Denis, Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-292-4184
Email: acostero@niaid.nih.gov

Mary E. Evans, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 301-594-4578
Email: evansmary@niddk.nih.gov

Abee Boyles, PhD
National Institute of Environmental Health Sciences (NIEHS)
Phone: 984-287-3241
E-mail: boylesa@mail.nih.gov

Megan Kinnane, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-443-3679
Email: megan.kinnane@nih.gov

Liz Perruccio, MS, PhD
National Institute of Nursing Research (NINR)
Telephone: 301-402-8084
Email: liz.perruccio@nih.gov

Arielle S. Gillman, PhD, MPH
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-402-1366
E-mail: arielle.gillman@nih.gov

Flora N Katz
Fogarty International Center (FIC)
Phone: 301-402-9591
E-mail: katzf@mail.nih.gov

Curt DellaValle, PhD, MPH
National Cancer Institute (NCI)
Telephone: 240-276-7225
Email: curt.dellavalle@nih.gov

Elizabeth A. Vogt, MPH
Office of Disease Prevention (ODP)
Phone: (301) 827-5576
E-mail: elizabeth.vogt@nih.gov

Regine Douthard, MD, MPH
Office of Research on Women's Health (ORWH)
Phone: 301.451.2729
E-mail: douthardr@mail.nih.gov

Peer Review Contact(s)
Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).

Financial/Grants Management Contacts
Margaret Young
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-642-4552
Email:
margaret.young@nih.gov

Tyrone A Smith
National Heart, Lung, and Blood Institute (NHLBI)
Phone: 301.827.8053
E-mail: smithty@mail.nih.gov

Philip Smith
National Institute on Aging (NIA)
Phone: 301-555-1212
E-mail: philip.smith2@nih.gov

Elizabeth Gutierrez
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 301-594-8844
Email: gutierrezel@niddk.nih.gov

Jenny L Greer
National Institute of Environmental Health Sciences (NIEHS)
Phone: 984.287.3332
E-mail: jenny.greer@nih.gov

Robert Munk
National Institute of Mental Health (NIMH)
Telephone:301-443-3034
Email: rmunk@mail.nih.gov

Ron Wertz
National Institute of Nursing Research (NINR)
Telephone: 301-594-2807
Email: wertzr@mail.nih.gov

Priscilla Grant, JD
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-594-8412
E-mail: pg38h@nih.gov

Victoria Quach Tran
Fogarty International Center (FIC)
Phone: none
E-mail: vicky.tran@nih.gov

Crystal Wolfrey
National Cancer Institute (NCI)
Telephone: 240-276-6277
Email: wolfreyc@mail.nih.gov