Key Dates
PAR-20-101 - Genomic Expert Curation Panels (U24 Clinical Trial Not Allowed)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
This notice informs the research community that the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to reissue Funding Opportunity Announcement (FOA) PAR-20-101, Genomic Expert Curation Panels (U24 Clinical Trial Not Allowed).
The FOA is anticipated to be published by the end of 2022, with an expected first application due date of May 27, 2023.
This Notice of Intent to Publish (NOITP) is being provided to allow sufficient time for applicants to assemble expert panels and develop strong applications.
The purpose of this FOA is to support teams of subject matter experts (expert panels) to evaluate the clinical validity of gene-disease relationships and the pathogenicity of individual genetic variants. Using standardized protocols for gene and/or variant annotation, these expert panels curate scientific evidence to systematically define the clinical relevance of genes and variants, which can then support the subsequent development of clinical practice guidelines. The work of these expert panels is overseen by the Clinical Genome Resource (ClinGen), a collaborative effort funded by the National Human Genome Research Institute (NHGRI) with co-funding from the National Cancer Institute (NCI). ClinGen serves as a centralized resource for precision medicine and research that openly shares the expert-curated clinical significance of genes and variants. Variants evaluated by ClinGen’s expert panels are deposited in ClinVar, a publicly and freely available database maintained by the National Center for Biotechnology Information (NCBI) that aggregates information about genomic variation and its relationships to human health.
This FOA will support both new and existing expert panels, which will be expected to collaborate with ClinGen and ClinVar. Expert panels will be required to use the ClinGen suite of curation interfaces and tools; submit their underlying data, curation procedures, and outcomes to ClinGen and ClinVar; and participate in ClinGen working groups. This FOA will not support the generation of new data, such as from functional assays, to support curation activities. The U24 activity code will be used for this FOA.
The proposed gene and variant curation expert panels should focus on determining the clinical significance of individual genes and genomic variants to diseases or disorders of high priority to the participating Institutes and Centers (ICs); the list of participating ICs will be available when the FOA is published later this year.
TBD
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application budgets for the three-year project period are limited to $220,000 per year in direct costs, and need to reflect the actual needs of the proposed project.
TBD
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government
Applications are not being solicited at this time.
Please direct all inquiries to:
Mollie Minear, PhD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
and Human Services (HHS)
