Notice of Intent to Publish a Funding Opportunity Announcement for Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network Clinical Research Centers
Notice Number:
NOT-HD-22-018

Key Dates

Release Date:
May 06, 2022
Estimated Publication Date of Funding Opportunity Announcement:
July 26, 2022
First Estimated Application Due Date:
November 30, 2022
Earliest Estimated Award Date:
July 01, 2023
Earliest Estimated Start Date:
July 01, 2023
Related Announcements

None

Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Purpose

The Eunice Kennedy ShriverNational Institute of Child Health and Human Development (NICHD) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications to participate in a research program cooperative agreement to support the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN). The Network will expand successes achieved by PATC3H to new geographic settings with limited implementation science (IS) research capacity and/or at-risk populations who are poorly represented in international adolescent HIV research (e.g., sexual and gender minorities; commercial sex workers; drug users) and stimulate much needed IS research in a neglected area of public health significance: prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). These settings must have an HIV epidemic density defined by UNAIDS estimates as either a country 1) in which at least 200,000 people are living with HIV and the number has not decreased by more than 5% over the last 2 consecutive years of available data or 2) has an HIV incidence among youth ages 10 to 24 years of 0.01% or more.

PATC3H-IN will consist of multiple highly integrated and interdependent functional components, including: (1) 4-5 UG1 Clinical Research Centers (CRC) [each Center will propose a study to be executed in at least 5 geographically distinct research performance sites, each of which must include partnerships between a national and/or regional health ministry or other local health authority and one or more community-based HIV-related service providers (e.g., hospital, clinic, non-government organization (NGO) or other relevant service provider)], (2) a single UM2 Coordination, Translation and Advanced Methods and Analytics Center (CTAMAC), and (3) a Scientific Leadership Committee (SLC) formed by representation from each CRC, the CTAMAC and NIH. The SLC will be responsible for PATC3H-IN governance, oversight and coordination, and will develop and implement the network research agenda, convening working groups as needed, prioritizing emerging research projects, efficiently managing the development of clinical protocols, implementing and completing clinical trials and ensuring timely publication and communication of results.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. To apply, investigators will be expected to demonstrate successful collaborations with local agencies and regulatory bodies, including policy makers and program leaders and implementers, to advance achievement of the research objectives and maximize sustainability of efficacious interventions and best practices.

The FOA is expected to be published in Summer 2022 with an expected application due date in Winter 2022.

This FOA will utilize the UG1 (Clinical Trial Optional) activity code for Clinical Research Centers and the UM2 (Clinical Trial Optional) activity code for the Coordination, Translation and Advanced Methods and Analytics Center. Details of the FOA are provided below.

Research Initiative Details

The Network will expand successes achieved by its predecessor, PATC3H, to new geographic settings and/or at- risk populations and stimulate much needed implementation science (IS) research in the prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific HIV prevention and/or HIV care continuum and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices.

The Network will conduct coordinated scientific inquiry to (1) improve understanding of the process of integration of research findings and evidence into public health, clinical practice and community settings and elucidate how to sustain uptake, adoption, and implementation of evidence-based interventions for youth who are at risk for or living with HIV in LMICs; (2) increase the scientific capacity and knowledgebase for IS research on at-risk, uninfected adolescents and those living with HIV in new geographies with limited IS research capacity and risk populations who are poorly represented in international adolescent HIV research (e.g., sexual and gender minorities; commercial sex workers; drug users); and (3) translate findings to inform national and global guidelines on the clinical management of at-risk, uninfected adolescents and those living with HIV in these regions. It is expected that the critical collaborative relationships with policy makers and key stakeholders needed for these applications will also lay the foundation for large scale implementation and sustainability after the grant cycle is over.

A pre-application webinar is planned for summer 2022.

Funding Information

TBD

Estimated Total Funding

TBD

Expected Number of Awards
TBD
Estimated Award Ceiling

TBD

Primary Assistance Listing Number(s)

TBD

Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization

Applications are not being solicited at this time. 

Inquiries

Please direct all inquiries to:

Bill G. Kapogiannis, M.D.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

301-402-0698