Notice of Intent to Publish a Funding Opportunity Announcement for Adolescent Medicine Trials Network for HIV/AIDS Intervention (ATN) Scientific Leadership Center (UM2 Clinical Trial Required), and Operations and Collaborations Center (UM1 Clinical Trial)
Notice Number:

Key Dates

Release Date:
September 07, 2021
Estimated Publication Date of Funding Opportunity Announcement:
October 29, 2021
First Estimated Application Due Date:
January 07, 2022
Earliest Estimated Award Date:
July 01, 2022
Earliest Estimated Start Date:
July 01, 2022
Related Announcements


Issued by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other NIH Institutes and Centers (ICs), the National Institute on Drug Abuse (NIDA) and the National Institute of Mental Health (NIMH), intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for a research program cooperative agreement to support the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) to develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide and vaccine trials in youth ages 13-24 years at-risk for HIV and living with HIV, with a focus on the inclusion of minors. This FOA will encourage a more focused, clinical research agenda, with increased emphasis on registrational trials of biomedical interventions. The ATN is the sole HIV clinical trials network focused exclusively on youth, and will continue to design, develop and conduct clinical trials as well as pertinent formative and implementation science research studies, and enroll youth participants into rigorously designed, collaborative protocols to address high-priority HIV research areas.

The ATN will include a UM2 Scientific Leadership Center (SLC) to include a Scientific Leadership Group, a Statistical and Data Management Core, and 5-8 Research Projects. . The ATN will also include a UM2 Operations and Collaborations Center (OCC) to include at least 8 Site Consortiums made up of established collaborations among clinics, academic universities, community-based organizations, health departments and other partners.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Fall 2021, with an expected application due date in Winter 2022.

This FOA will utilize the UM2 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of HIV/AIDS among adolescent and young adults populations to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise in HIV/AIDS, demonstrated leadership and administrative capabilities, and design of multidisciplinary research projects, including basic and clinical research will be encouraged and these investigators should also begin considering applying for this application.

Among the areas of research encouraged in this initiative are studies to investigate HIV priority areas of undiagnosed HIV infection, persistent new infections, poor HIV care engagement, poor ART adherence, viral suppression, and adverse HIV health outcomes from COVID-19, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of HIV/AIDS.

Funding Information
Estimated Total Funding

To be determined (TBD)

Expected Number of Awards

The ATN will be composed of 1 UM2 SLC and 1 UM2 OCC.

Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Sonia Lee, Ph.D.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


Weekly TOC for this Announcement
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