September 29, 2020
PA-20-185- NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-18-480- NICHD Research Project Grant (Parent R01 Clinical Trial Required)
PA-20-200 - NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
The purpose of this Notice of Special Interest is to encourage applications in three areas related to the intersection of COVID-19, the associated mitigation actions, and rehabilitation:
Research applications addressing these topics are considered responsive; not all topics are expected within the same application. Applications will be directed to the National Center for Medical Rehabilitation Research (NCMRR) at NICHD.
About 15- 20% of people who contract SARS CoV-2 will develop a severe case of COVID-19. Ever improving developments in medical care means that a substantial majority of those people will survive. Early reports suggest that rehabilitation is required to restore pre-COVID-19 function.In particular, rehabilitation has been suggested for pulmonary and cardiac sequalae, post ICU syndrome, deconditioning and muscle wasting, dysphagia, neurological symptoms, and other sequalae from severe COVID-19 disease. While treatments are being informed by previous coronavirus outbreaks resulting in acute respiratory distress syndrome, rehabilitation from sepsis or other similar diseases, the particular needs of COVID-19 survivors and the efficacy of rehabilitation on these patients has not been studied; nor has the extent to which these rehabilitation services have been offered or utilized by survivors been reported.
People with physical disabilities are at particular risk for contracting SARS-CoV2 because mitigation strategies such as social distancing and increased hand washing may not be possible due to caregiving needs. Outbreaks of the virus in group homes and skilled nursing facilities suggest special attention is required to keep vulnerable populations from contracting or spreading the virus.Moreover, major disruptions in routine rehabilitation services have been reported as part of the mitigation strategies during the pandemic. Understanding the current rehabilitation landscape is necessary to inform future interventions.
This NOSI invites research applications on the rehabilitation needs of COVID-19 survivors. At present, the best acute rehabilitation plan for people who have recovered from severe cases of COVID- 19 is unknown. Similarly, the long-term rehabilitation needs and sequalae of people who recover from COVID-19 are not well understood. Furthermore, the interplay of existing physical disabilities and recovery from COVID-19 is also unknown.
Research applications are also sought to understand the impact of disruptions to rehabilitation services caused by the COVID-19 pandemic and associated mitigation actions. Applications that measure the impact of delayed treatment for common disabling conditions, such as stroke, are also sought.
Finally, research applications investigating the social, behavioral, and economic impact of COVID-19 on people with physical disabilities and their caregivers are requested.
Topics of interest include but are not limited to:
Application and Submission Information
This notice applies to due dates on or after February 5, 2021 and subsequent receipt dates through May 8, 2023.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Applicants planning to submit an application in response to this NOSI are strongly encouraged to contact the NICHD scientific/programmatic contact(s) listed on this NOSI in advance of the application due date
Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.
Theresa Cruz, PhD.
Eunice Kennedy Shriver?National Institute of Child Health and Human Development (NICHD)