Notice Number: NOT-HD-19-023

Key Dates
Release Date: September 20, 2019
First Available Due Date: February 5, 2020
Expiration Date: September 8, 2022

PA-19-056 : Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-18-480: NICHD Research Project Grant (R01 Clinical Trial Required)

PA-18-482: NICHD Exploratory/Developmental Research Grant (R21 - Clinical Trial Optional)

Issued by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Purpose

The purpose of this Notice of Scientific Interest (NOSI) is to continue a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). MODS is a clinical condition commonly encountered in the pediatric intensive care unit that is associated with significant morbidity and mortality. It is characterized by the failure or dysfunction of a consistent group of body organs or organ systems. It is triggered by a wide range of disease processes and clinical insults, most notably sepsis and trauma, and is frequently associated with uncontrolled inflammation. Despite its high prevalence and unfavorable outcomes, this clinical entity remains poorly understood. First described over 40 years ago, it still can only be described as a “syndrome,” a constellation of symptoms, rather than as a specific pathologic entity with a distinguishable cause. The current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Applications may include any appropriate study design ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research solicited through this NOSI, outcomes will improve both in terms of the prevention and treatment of MODS in children.

Topics of Interest

Topics to be addressed by this NOSI include any areas where knowledge gaps exist and research needs remain in the understanding and management of pediatric MODS. To address these needs, a wide range of science must be conducted ranging from basic science molecular and genomic studies up to large scale, longitudinal epidemiology projects and clinical trials. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications in response to this NOSI should address one or more of the following five priority areas:

Epidemiology and Outcomes

• Studies directed at developing and validating new definitions of the syndrome that are evidence-based and expanded to include contemporary data such as biomarker levels.
• Studies designed to secure large scale epidemiology data needed to most completely understand the precipitants of the syndrome, assess the magnitude of the problem and establish the long-term outcomes beyond simply hospital survival.

Detection and Monitoring of MODS

• Studies aimed at the re-assessment of clinical criteria for diagnosing and monitoring the progression of MODS given advancements in monitoring capabilities over time.
• Studies designed to identify associations between biomarker levels and MODS; identified relationships must be further validated in prospective, multicenter study, and performed in a manner to be clinically relevant.
• Studies attempting to identify unique endotypes and phenotypes that may exist among those given the global diagnosis of MODS.
• Studies that test novel techniques and technologies used in the diagnosis and monitoring of MODS which may include, but are not limited to, the following:
• Mechanistic, mathematical modeling
• Redox monitoring
• Assessment of heart and respiratory rate variation
• Continuous, real-time assessment of biomarker levels
• Non-invasive monitoring of biomarkers through sweat and other mechanisms

Pathophysiology

• Studies directed at elucidating the complex, inter-related pathophysiologic processes associated with this condition.
• Studies aimed at identifying mechanisms common to all MODS patients as well as those developed to characterize pathophysiologic features unique to specific phenotypes.
• Basic science studies designed to identify the most rudimentary cause of the syndrome at a molecular, cellular and genomic level that can then be advanced into translational and clinical projects.
• Studies focused on specific pathophysiologic processes that include, but are not limited to, any of the following:
• The role of damage-associated molecular pattern molecules (DAMPs) and pathogen-associated molecular pattern molecules (PAMPs)
• Hyperinflammatory syndromes
• Thrombocytopenia-associated multiple organ failure
• Mitochondrial dysfunction
• Immunoparalysis
• Endothelial and epithelial injury
• Alterations in redox potentials
• Gastrointestinal perturbations
• Alterations in the microbiome

Specific Triggering Etiologies

• Studies focused on the assessment of MODS within specific disease categories (e.g. MODS among children with sepsis, cancer, acute respiratory distress syndrome, congenital heart disease, inborn errors of metabolism, etc.).
• Studies designed to compare MODS across different disease categories identifying key similarities and differences in terms of pathophysiology, epidemiology, and outcomes.
• Studies directed at the assessment and occurrence of MODS in children who have experienced external injury such as trauma and burn victims.
• Studies aimed at minimizing the occurrence of MODS associated with therapeutic interventions such as blood transfusions, medications, and organ and stem cell transplantation.

Promising Therapies

• Exploratory studies to assess novel therapeutic interventions in the treatment of MODS. Studies of the use of anti-cytokine antibodies, anti-toxin therapies, and anti-oxidant interventions represent but a few potential examples.
• Large scale, multicenter, prospective clinical studies to assess the true value of therapies found to be effective in case series and small, uncontrolled trials.
• Comparative effectiveness studies designed to identify the most effective therapies across centers including optimal supportive care.
• Studies designed to assess and identify differences in responsiveness to therapies among all pediatric MODS patients.

Application and Submission Information

This Notice applies to due dates on or after February 5, 2020 and subsequent receipt dates through September 8, 2022.

Submit applications for this initiative using one of the following FOAs or any reissues of these announcements through the expiration date of this Notice.

• PA-19-056: Research Project Grant (Parent R01 Clinical Trial Not Allowed)
• PA-18-480: NICHD Research Project Grant (R01 Clinical Trial Required)
• PA-18-482: NICHD Exploratory/Developmental Research Grant (R21 - Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and referenced FOAs must be followed, with the following additions:

• For funding consideration, applicants must include "NOT-HD-19-020" (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B, or non-responsive to the terms of this NOSI will not be considered for this NOSI initiative.
• Applicants planning to submit an application in response to this NOSI are strongly encouraged to contact the NICHD scientific/programmatic contact(s) listed on this NOSI in advance of the application due date.

Applications nonresponsive to terms of this NOSI will be not be considered for the NOSI initiative.

Inquiries