Notice of Intent to Publish a Funding Opportunity Announcement for Developmental Mechanisms of Human Structural Birth Defects (P01)

Notice Number: NOT-HD-15-002

Key Dates
Release Date:   February 26, 2015
Estimated Publication Date of Announcement:  Spring 2015 
First Estimated Application Due Date:  Fall 2015 
Earliest Estimated Award Date:  Summer 2016 
Earliest Estimated Start Date:  Summer 2016 

Related Announcements

Issued by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


The Eunice Kennedy Shriver National Institute of Child Health and Human Development intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for research on developmental defects of generalized body patterning and localized dysmorphic anomalies of various systems (e.g., skeletal, nervous, or visceral) that lead to clinically significant and major congenital structural malformations.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Spring 2015 with an expected application due date in Fall 2015.

This FOA will utilize the P01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages basic scientists and physician scientists with expertise and insights into developmental biology and structural birth defects research to consider applying for this RFA.

Collaborative, synergistic Program Projects (P01) Grants comprised of three component projects and associated cores focusing on a specific structural birth defect will be solicited.  The proposed research should integrate basic, translational, and/or clinical approaches to understanding the developmental biology and genetic basis of the structural birth defect.  At least one project must use basic research in an animal model system and at least one project must be clinical or translational in nature. The component projects must share a common central theme, focus, or objective on a specific developmental defect or malformation that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans.

The areas of research encouraged in this initiative will be studies that examine the mechanisms underlying structural birth defects, including but not limited to the role of quantitative aspects of development (such as gene dosage, copy number variation, or modifier genes) as well as studies designed to improve the translation of existing knowledge into treatment and/or prevention of the structural defect.  While applications focusing on developmental disorders that result in intellectual disabilities and related neurobehavioral disabilities are of interest to the NICHD, they are outside the scope of this FOA. However, syndromic conditions, which exhibit intellectual disability as part of the phenotype, are acceptable as long as the focus of the project is on associated structural birth defects.



Please direct all inquiries to:

Lorette C. Javois, Ph.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-435-6890