Request for Proposals (RFP): Repository of Mouse Models for Cytogenetic Disorders

Notice Number: NOT-HD-10-004


Key Dates
Release Date:  April 23, 2010

Issued by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (


The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Center for Developmental Biology & Perinatal Medicine (CDBPM) has a requirement for a repository to develop and maintain mouse models of genetic diseases.  The objective of this contract will be to produce, maintain, and distribute aneuploid mice with a primary emphasis on chromosome 16 as a model of human trisomy for chromosome 21.

If selected for this requirement, the Contractor will breed mice and refine methodologies to produce the various strains of mice and to maintain their genetic fidelity.

The work will involve the following essential activities:  1) Maintenance of the “Repository for Mouse Models of Cytogenetic Disorders” or “Cytogenetic Resource;”  2)  Breed various strains of mice with known genetic background, which will produce chromosomally unbalanced gametes, resulting in trisomic and monosomic embryos with special emphasis on chromosome 16, but including relevant regions of chromosome 17 and chromosome 10;  3) Refine procedures to cryopreserve embryos that will be rescued by thawing and re-implanting them in pseudo-pregnant mice; 4) Distribute the animal models to qualified investigators approved by the NICHD; 5) Test the animals periodically for pathogens; 6)  Publicize the availability of mouse models indicating the type of strains in the colony as well as detailed information about the strain phenotype, genotype, protocols for genotyping, husbandry conditions, and other details as specified by the Project Officer; 7) Characterize the clinical and behavioral phenotype of the mouse models to ensure integrity of the strains, especially for any new strains offered by the Contractor or as specified by the Project Officer.

It is anticipated that one cost-reimbursement, completion type contract will be awarded, with a period of performance of 5 years, beginning approximately July 1, 2010. RFP-NIH-NICHD-CDBPM-10-11 will be available electronically on or about April 8, 2010 with a closing date tentatively set for May 7, 2010 and may be accessed through the FedBizOpps or through the NICHD website at, Research and Development Contracts, Contract Opportunities – Federal Business Opportunities.  Any responsible offeror may submit a proposal that will be considered by the Government.  This advertisement does not commit the Government to award a contract. 


No collect calls will be accepted. For further information, contact:

Katharine C. Minker
Contract Specialist
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institutes of Health, Department of Health and Human Services
6100 Executive Boulevard, Room 7A-07, MSC 7510
Bethesda, MD 20892-7510
EXPRESS/COURIER: Rockville, MD 20852
Phone: (301) 402-7571

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