Notice of Intent to Publish a Funding Opportunity Announcement for Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
November 08, 2022
Estimated Publication Date of Funding Opportunity Announcement:
May 01, 2023
First Estimated Application Due Date:
October 03, 2023
Earliest Estimated Award Date:
July 01, 2024
Earliest Estimated Start Date:
July 01, 2024
Related Announcements

PAR-20-117 - Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (R35 - Clinical Trial Optional)

Issued by

National Institute of General Medical Sciences (NIGMS)


The purpose of this Notice is to inform the biomedical research community that NIGMS is planning to issue a Funding Opportunity Announcement (FOA) to continue the Maximizing Investigators’ Research Award for Early Stage Investigators (MIRA-ESI) (R35) program. The FOA is intended for new applications from Early Stage Investigators.

This Notice is being provided to allow potential applicants sufficient time to develop responsive projects.The FOA is expected to be published in Spring 2023 with an expected first application due date in October 2023. This FOA will utilize the R35 activity code.

Research Initiative Details

The NIGMS MIRA-ESI FOA is intended to provide support for the program of research in an ESI's laboratory that falls within the mission of NIGMS. ESIs are encouraged to submit an application early in their independent research careers and to move into research areas that are distinct from those of their postdoctoral mentors. Applicants who have not yet received independent research funding are encouraged to apply, as are those who have not had sufficient time and/or resources to generate independent senior author publications. Preliminary data are neither required nor expected, but if provided will be evaluated during the review process. Because the MIRA is intended to support a significant and ambitious program of research, the PD/PI is required to devote at least 51% of his/her total research effort to this award. MIRA-ESI applications are reviewed separately from established investigator MIRA applications.

Anticipated changes in this FOA reissuance include: (1) providing two application receipt dates per year - February and October; and (2) requiring a Plan for Enhancing Diverse Perspectives. Review criteria will be revised accordingly, and reviewers will be oriented to these new FOA goals.

Funding Information


Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization

Applications are not being solicited at this time. 


Please direct all inquiries to:

Sailaja Koduri, Ph.D.
National Institute of General Medical Sciences (NIGMS)