Notice of Intent to Publish a Funding Opportunity Announcement for Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (R35 - Clinical Trial Optional)

Notice Number: NOT-GM-19-061

Key Dates

Release Date: October 07, 2019
Estimated Publication Date of Funding Opportunity Announcement: May 01, 2020
First Estimated Application Due Date: October 05, 2020
Earliest Estimated Award Date: July 01, 2021
Earliest Estimated Start Date: July 01, 2021

Related Announcements

Issued by
National Institute of General Medical Sciences (NIGMS)


The purpose of this Notice is to inform the biomedical research community that NIGMS is planning to issue a funding opportunity announcement (FOA) to continue the Maximizing Investigators’ Research Award for Early Stage Investigators (MIRA-ESI) (R35) program . The FOA is intended for new applications from early stage investigators .

This Notice is being provided to allow potential applicants sufficient time to develop responsive projects.

The FOA is expected to be published in Spring 2020 with an expected first application due date in October 2020.

This FOA will utilize the R35 activity code. Details of the planned FOA are provided below.

Research Initiative Details

An NIGMS MIRA for ESIs is intended to provide support for the program of research in an ESI’s laboratory that falls within the mission of NIGMS. Investigators receiving a MIRA will be required to relinquish their other NIGMS research funding, including Mentored Career Development (K) awards. Investigators with K awards from another Institute/Center of the NIH may receive an NIGMS MIRA but will be required to adjust their person-months of effort on those awards to be less than the number of person-months committed to the MIRA. MIRA PIs who received support from the NIGMS research grants of other investigators (for example, serving as collaborators and subcontractors on R01s and as project leaders on P01, P20, or P50 subprojects) will no longer be able to receive funds from those sources. MIRA-ESI applications will be reviewed separately from established investigator MIRA applications by broadly-based review panels within the Center for Scientific Review.

With the reissuance of the MIRA-ESI FOA, NIGMS intends to make the following changes: 1) encourage eligible applicants to apply earlier in their independent research career; 2) enhance applicants’ ability to move into research areas that are distinct from those of their postdoctoral mentors; and 3) emphasize that preliminary data are neither required nor expected. Review criteria will be revised accordingly, and reviewers will be oriented to these new FOA goals.

Funding Information

Estimated Total Funding TBD
Expected Number of Awards TBD
Estimated Award Ceiling $250,000
Primary CFDA Numbers 93.859

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Michele McGuirl, Ph.D.
National Institutes of General Medical Sciences (NIGMS)

Sailaja Koduri, Ph.D.
National Institutes of General Medical Sciences (NIGMS)