Request for Information (RFI): Strategies for Advancing Sepsis Research Supported by NIGMS

Notice Number: NOT-GM-18-039

Key Dates
Release Date: July 23, 2018
Response Date: August 31, 2018

Related Announcements

Issued by
National Institute of General Medical Sciences (NIGMS)


The National Institute of General Medical Sciences (NIGMS) seeks input on approaches to advance an understanding of the mechanisms of sepsis and its resolution and to accelerate translation of this understanding into early detection strategies and improved therapies.


Although NIGMS is not the only source of federal funding for sepsis research, the Institute supports a substantial portfolio of research that includes both fundamental and clinical studies, from the molecular to the organismal, that emphasize the host's response rather than causative factors such as infection or injury. NIGMS does not support sepsis-related outcomes and health services research, clinical implementation, or public health research. In an effort to more rapidly move NIGMS’ sepsis research program and its translation forward, NIGMS through this Request for Information (RFI) seeks to obtain feedback, comments, novel ideas and strategies that address the challenges and opportunities in sepsis research to accelerate advances in detection of and treatment for this condition.

Information Requested

NIGMS seeks input from key extramural community stakeholders, including clinicians, researchers in academia and industry, and scientific societies and advocacy organizations, as well from interested members of the public, on strategies to advance sepsis research supported by NIGMS. Topics that could be addressed include, but are not limited to, the following:

  • The current barriers that hinder advancement of research related to sepsis;
  • Gaps in currently supported research areas and approaches;
  • Utility of current animal models, including the possible use of research organisms other than the standard mouse models;
  • The appropriate mix of fundamental and clinical sepsis research; and
  • The need, if any, for shared resources.

How to Submit a Response

Responses to this RFI will be accepted through August 31, 2018 . All comments will be anonymous and must be submitted via a web form at

Responses to this RFI are voluntary. The Government is under no obligation to acknowledge receipt of the information provided and respondents will not receive individualized feedback. This RFI is for planning purposes only and should not be construed as a solicitation or as an obligation on the part of the United States Government. NIGMS will use the information submitted in response to this RFI at its discretion. NIGMS does not intend to make any type of award based on responses to this RFI or to pay for either the preparation of information submitted or the United States Government's use of such information.

The information submitted will be analyzed and may be shared internally, appear in reports or be reflected in future solicitations, as appropriate and at the Government's discretion. Proprietary, classified, confidential, or sensitive information should not be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s) or other activities. No basis for claims against the U.S. Government shall arise as a result of a response to this request for information or from the Government's use of such information.


Please direct all inquiries to:

Judith H. Greenberg, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Telephone: 301-594-2172