National Eye Institute (NEI)
The NEI intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on in vivo models for translation-enabling research related to neural regeneration in the visual system. The complexity of generating new models and testing molecular or cell-based therapies will require collaborative teams with complementary expertise.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in July 2020 with an expected application due date in October 2020.
This FOA will utilize the U24 activity code. Details of the planned FOA are provided below.
The NEI Audacious Goals Initiative (AGI) is aimed at restoring vision through the regeneration of neurons in the visual system, with special emphasis on photoreceptors and retinal ganglion cells. Significant obstacles are expected in translating recent advances from current animal models of neural regeneration toward potential therapeutic approaches in humans. The purpose of this FOA is to encourage research that evaluates the survival and functional integration of regenerated neurons in translation-enabling, in-vivo models that are closer to human anatomy and physiology.
This Notice encourages investigators to form collaborative teams with expertise in the structure and function of the human visual system, diseases of the visual system, stem cell biology and/or gene therapy to consider applying for this new FOA.
The areas of research encouraged in this initiative include:
Replacing retinal neurons using transplantation of stem cells or stem-cell derivatives
Non-human primate models for evaluating survival and integration of regenerated photoreceptors or retinal ganglion cells that enable preclinical development and clinical testing of potential human therapies are strongly encouraged and will receive priority consideration.
APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.
Applications are not being solicited at this time.
Please direct all inquiries to:
Thomas Greenwell, PhD
National Eye Institute, NEI