Notice of Request for Proposals for Operating the Respiratory Toxicology Group (RTOX) Inhalation Facility and Performing Animal Studies

Notice Number: NOT-ES-06-012

Key Dates
Release Date: May 19, 2006

Issued by
National Institute of Environmental Health Sciences (NIEHS), (

The purpose of this notice is to announce a request for proposal RFP NIH-ES-06-05.  The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposals for the purpose of providing and operating the Respiratory Toxicology Group (RTOX) inhalation facility and performing animal studies. This includes setting up the inhalation facility in a suitable building provided by the contractor; conducting the daily operation of the exposure facility; operating an animal facility; and conducting studies as directed by study protocols.

The mandatory qualification criteria of the inhalation facility being located within 15 minutes driving time of the NIEHS main campus, 111 T.W. Alexander Drive, Research Triangle Park, NC  27709 must be met at the time of award. 

The contractor shall provide 1)  an inhalation exposure facility and staff dedicated exclusively to the support of NIEHS studies; 2) on-site space for the NIEHS Respiratory Toxicology Group  which is independently secured from the rest of the facility; and  3) all components of the Inhalation Facility and the support areas including offices and laboratories shall be located on one site. 

The technical capabilities of the inhalation exposure facility have been tailored specifically to support the research needs of the Respiratory Toxicology Group and other groups within the Institute.  Flexibility is a major factor in the design and operation of the exposure facility.  The specific types of inhalation studies to be performed will be entirely dependent on the Institute’s needs for inhalation research.  Exposure systems have been designed to allow configuration for a variety of study designs with a minimum of custom modifications. Computer control of exposures provides a safe, well controlled, and well-documented exposure environment.  The contractor shall maintain complete and up-to-date documentation of all technical aspects of the facility design and operations.  An inhalation facility is composed of four (4) distinct work areas - exposure, animal care, technical support, and staff areas.

Total approximate facility space = 13,000 square feet. Approval of final configuration of the facility rests with the government.

It is anticipated the resulting cost-reimbursement, level-of-effort contract will be for a period of 4 year and 3, 2-year option periods. For estimating purposes the Government estimated the level-of effort at 43,524 direct labor hours per year as follows:  Professional – 9579 direct labor hours ;Technical - 7440 direct labor hours); Animal Husbandry Staff – 26,040 direct labor hours; Administrative Support - 465 direct labor hours.

The specific studies will be designed based on research requirements originating within the NIEHS.  It is not possible to anticipate the specific projects in advance.            

The contract will include Government Furnished Equipment (GFE) such as computers and specialized inhalation studies equipment.  Contractor provided material shall include genetically altered rats/mice; general office supplies; and animal supplies such as tyvek suits and bedding; and all anesthetics, drugs and controlled substances used in veterinary medicine.

Proposals to this solicitation are due on June 26, 2006.  Interested organizations should fax a request for RFP NIH-ES-06-05 to the attention of Carolyn N. Flowers, Contract Specialist at (919) 541-2712 or send an e-mail request to All responsible sources may submit a proposal, which shall be considered by the Agency. The electronic version of the FedBizOpps synopsis is available at: This requirement is unrestricted. NAICS Code is 541710.


Written requests should reference RFP NIH-ES-06-05 and forwarded to:

National Institute of Environmental Health Sciences
Office of Acquisitions, Office of Management
ATTN:  Carolyn Flowers, Contract Specialist
79 TW Alexander Drive, Building 4401
P.O. Box 12874, EC-02
Research Triangle Park, NC 27709-2233
Phone: 919-541-0425
Fax: 919-541-2712

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