STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF 
ALPHA-PINENE AND VINYLIDENE CHLORIDE IN LABORATORY ANIMALS VIA 
INHALATION FOR THE NATIONAL TOXICOLOGY PROGRAM

RELEASE DATE:  July 1, 2003

NOTICE: NOT-ES-03-011

National Institute of Environmental Health Sciences (NIEHS)
 (http://www.niehs.nih.gov/)

The purpose of this notice is to announce a request for proposal
(NIH-ES-03-19) (http://www.niehs.nih.gov/dert/rcb/rfp.htm).  The NIEHS 
is soliciting offers for a contract to evaluate the toxicologic and 
carcinogenic potential of the following chemicals via inhalation: 
alpha-Pinene and Vinylidene Chloride.  The base contract (designated as 
Phase 1) shall include work activities associated with the identity and 
purity determination of bulk chemical, development of generation and 
monitoring methods, health and safety concerns that must be addressed 
before study start, and conduct of 14-day studies of alpha-Pinene and 
Vinylidene Chloride.  Upon successful completion of Phase 1, the 
Government may unilaterally exercise options for the conduct of 90-day 
or 2-year studies specified as Phases 2 through 3, respectively.  
Multiple studies shall be conducted concurrently in accordance with the 
"Specifications for the Conduct of Studies to Evaluate the Toxic and 
Carcinogenic Potential of Chemical, Biological and Physical Agents in 
Laboratory Animals for the National Toxicology Program (NTP)dated 
September 2000".  Offerors shall have a working laboratory in place by 
the date of proposal submission.  The Principal Investigator, 
Toxicologist, Chemist, Engineer/Exposure Specialist, Veterinarian, 
Health and Safety Officer and Quality Assurance Unit Officer shall be 
employees of the contract laboratory (i.e., not consultants or 
subcontractors).  The daily interaction and constant coordination of 
efforts needed amongst these discipline areas throughout the in-life 
portion of the studies makes it critical that they be physically and 
organizationally together.  Award of one cost-reimbursement, completion 
type contract on approximately February 27, 2004 on an open competition 
basis is contemplated as a result of this solicitation.  The estimated 
level of effort is 6,750 labor hours for the base contract and 71,200 
labor hours for all options.  The estimated period of performance is 
approximately seven months for the base contract and four years two 
months if all options are exercised.   Interested organizations should 
telefax a request for RFP NIH-ES-03-19 to the attention of Mr. David 
Sedgley, Procurement Technician at (919) 541-2712 or send an e-mail 
request to [email protected].   The electronic version of the 
FedBizOps synopsis will be available on the Internet at:  
http://www.niehs.nih.gov/dert/rcb/rfp.htm.  An electronic copy of the 
RFP (without the NTP Specifications) will be posted to this site on or 
about July 15, 2003.   All responsible sources may submit a proposal which 
shall be considered by the Agency.  Expected release date of the RFP 
is July 15, 2003 with proposals due August 29, 2003.  This requirement 
is unrestricted.  NAICS Code is 541710.

Requests should reference RFP NIH-ES-03-19 and should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN:  Marilyn B. Whaley, Contract Specialist
79 T.W. Alexander Drive, 4401 Building
P. O. Box 12874
Research Triangle Park, NC  27709

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