Release Date:  July 12, 2001

NOTICE:  NOT-ES-01-010

RFP NIH-ES-01-15

National Institute of Environmental Health Sciences

The NIEHS is soliciting offers for a contract to evaluate the 
toxicologic and carcinogenic potential of SAN-Trimer.  The base
contract (designated as Phase 1) shall consist of work activities
associated with the determination of bulk chemical analysis (identity
and purity) and validation of dose formulation and analysis procedures.  
Upon successful completion of Phase 1, the Government may unilaterally 
exercise options for the conduct of 7-week, 18-week, and 2-year studies 
specified as Phases 2 through 4, respectively.  These studies shall be 
conducted according to the Specifications for the Conduct of Studies to 
Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological 
and Physical Agents in Laboratory Animals for the National Toxicology 
Program dated September 2000.  Offerors shall have a working laboratory 
in place by the date of proposal submission.  The Principal 
Investigator, Toxicologist, Chemist, Veterinarian, Health and Safety 
Officer and Quality Assurance Unit Officer shall be employees of the 
contract laboratory (i.e., not consultants or subcontractors).  The 
daily interaction and constant coordination of efforts needed amongst 
these discipline areas throughout the in-life portion of the studies 
makes it critical that they be physically and organizationally 
together.  Award of one cost-reimbursement, completion type contract on 
April 30, 2002 on an open competition basis is contemplated as a result 
of this solicitation.  The estimated level of effort is 320 labor hours 
for the base contract and 25,425 labor hours for all options.  The 
estimated period of performance is approximately four months for the 
base contract and four years eight months if all options are exercised.     
Interested organizations should telefax a request for RFP NIH-ES-01-15 
to the attention of Ms. Melissa Gentry, Procurement Technician at  
(919) 541-2712 or send an e-mail request to    
The electronic version of the CBD synopsis is available on the Internet 
at:  An electronic copy of 
the RFP (without the NTP Specifications) will be posted to this site on 
or about July 24, 2001.   All responsible sources may submit a proposal
which shall be considered by the Agency.  Expected release date of the
RFP is July 24, 2001 with proposals due September 21, 2001.  This
requirement is unrestricted.  NAICS Code is 541710.

Requests should reference RFP NIH-ES-01-15 and  be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN: Ms. Jackie Osgood,  Contracting Officer
79 T.W. Alexander Drive, 4401 Building
P. O. Box 12874
Research Triangle Park, NC  27709

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