NOT-ES-01-008: STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

Department of Health
and Human Services (HHS)
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STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

Release Date:  June 21, 2001

NOTICE:  NOT-ES-01-008

RFP NIH-ES-01-09

National Institute of Environmental Health Sciences

The purpose of this project is to obtain detailed chemical disposition
data from 3 to 6 studies per year of selected environmental
contaminants or model compounds per year.  The purpose of this
contract is to procure detailed chemical disposition data from a
number of selected environmental contaminants or model compounds per
year. Most of these studies will be conducted in Fischer 344 rats
and/or B6C3F1 mice. There are infrequent occasions where other strains
of rats (e.g. Sprague-Dawley) or mice (e.g. Swiss-Webster) will be
required to meet the needs of the NTP.  Rarely, other laboratory
rodent species such as hamsters will be required.  (Note:   For
costing purposes, offerors should assume that all studies will be
conducted in Fischer 344 rats and/or B6C3F1 mice.)  Most studies will
address the disposition of organic chemicals, however, studies of
inorganic chemicals may also be requested. Individual studies may vary
in complexity from preliminary investigations of chemical absorption
to detailed studies of all phases of chemical disposition,
toxicokinetics, and metabolism.  The immediate goal of these studies
is to provide data to be used in determination of dose, route of
administration, and interpretation of NTP bioassay studies. The
long-range goal is the accumulation of data that will permit a better
assessment of structure-activity relationships for chemical
absorption, metabolism, and disposition in laboratory animals and to
better interpret the significance of these data to humans.  This
project will cover a five year period with two awards.  This project
will cover a five year period with two awards.  The government
estimates that the project will require approximately 2.0 professional
person-years and 3.0 technical person years per contract year.
Requests must reference RFP No. NIH-ES-01-09 and must be directed to
the office listed below.  Release of the RFP is anticipated on or
about July 13, 2001 with proposals due August 14, 2001.  All
responsible sources may submit a proposal which shall be considered by
the Agency.

Requests should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN:  Howard Hill, Contract Specialist
79 T.W. Alexander Drive, Building 4401 Research Commons
P.O. Box 12874
Research Triangle Park, NC  27709
(919) 541-4971 (Telephone)
(919) 541-2712 (Fax)
[email protected]
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